Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems

被引：199
作者：
Schwendeman, SP [1 ]
机构：
[1] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
来源：
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS | 2002年 / 19卷 / 01期
关键词：
protein stability; poly(lactide-co-glycolide); encapsulation; vaccine stability; antigen;
D O I：
10.1615/CritRevTherDrugCarrierSyst.v19.i1.20
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Injectable controlled-release systems based on biodegradable copolymers of lactic and glycolic acids (PLGAs) have become widely used for delivery of protein therapeutics and vaccine antigens. Over the last five years, great strides have been made toward overcoming the difficulty of stabilizing PLGA-encapsulated proteins. In addition to stabilizing proteins during encapsulation with anhydrous methods, two approaches have proven highly, effective to stabilize proteins during 1-month release incubation under physiological conditions: protein complexation with zinc and control of PLGA microclimate pH with antacid excipients. Described here are recent advances in the stabilization of proteins encapsulated in PLGA delivery systems.
引用
收藏
页码：73 / 98
页数：26
相关论文
共 117 条
[41]   A large-scale process to produce microencapsulated proteins [J].
Herbert, P ;
Murphy, K ;
Johnson, O ;
Dong, N ;
Jaworowicz, W ;
Tracy, MA ;
Cleland, JL ;
Putney, SD .
PHARMACEUTICAL RESEARCH, 1998, 15 (02) :357-361
[42]  
Jiang WL, 2000, BIOTECHNOL BIOENG, V70, P507, DOI 10.1002/1097-0290(20001205)70:5<507::AID-BIT5>3.3.CO
[43]  
2-3
[44]   Stabilization and controlled release of bovine serum albumin encapsulated in poly(D, L-lactide) and poly(ethylene glycol) microsphere blends [J].
Jiang, WL ;
Schwendeman, SP .
PHARMACEUTICAL RESEARCH, 2001, 18 (06) :878-885
[45]   Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives [J].
Johansen, P ;
Men, Y ;
Audran, R ;
Corradin, G ;
Merkle, HP ;
Gander, B .
PHARMACEUTICAL RESEARCH, 1998, 15 (07) :1103-1110
[46]   Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination [J].
Johansen, P ;
Men, Y ;
Merkle, HP ;
Gander, B .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 50 (01) :129-146
[47]   A month-long effect from a single injection of microencapsulated human growth hormone [J].
Johnson, OL ;
Cleland, JL ;
Lee, HJ ;
Charnis, M ;
Duenas, E ;
Jaworowicz, W ;
Shepard, D ;
Shahzamani, A ;
Jones, AJS ;
Putney, SD .
NATURE MEDICINE, 1996, 2 (07) :795-799
[48]   The stabilization and encapsulation of human growth hormone into biodegradable microspheres [J].
Johnson, OL ;
Jaworowicz, W ;
Cleland, JL ;
Bailey, L ;
Charnis, M ;
Duenas, E ;
Wu, CC ;
Shepard, D ;
Magil, S ;
Last, T ;
Jones, AJS ;
Putney, SD .
PHARMACEUTICAL RESEARCH, 1997, 14 (06) :730-735
[49]  
JONES AJS, 1994, ACS SYM SER, V567, P22
[50]   ANALYSIS OF POLYPEPTIDES AND PROTEINS [J].
JONES, AJS .
ADVANCED DRUG DELIVERY REVIEWS, 1993, 10 (01) :29-90
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