Novel Approaches to Preventing Ischemia-Reperfusion Injury During Liver Transplantation

被引：43

作者：

Akhtar, M. Z. ^{[1
,2
]}

Henderson, T. ^{[3
]}

Sutherland, A. ^{[2
]}

Vogel, T. ^{[2
]}

Friend, P. J. ^{[1
,2
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Oxford OX3 9DU, England

[2] John Radcliffe Hosp, Oxford Transplant Ctr, Oxford OX3 9DU, England

[3] Univ Oxford, John Radcliffe Hosp, Sch Med, Oxford OX3 9DU, England

来源：

TRANSPLANTATION PROCEEDINGS | 2013年 / 45卷 / 06期

基金：

英国医学研究理事会;

关键词：

HEART-BEATING DONORS; CAROLINA RINSE SOLUTION; SINUSOIDAL ENDOTHELIAL-CELLS; RANDOMIZED CONTROLLED-TRIAL; PLATELET-ACTIVATING-FACTOR; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL PERMEABILITY TRANSITION; HEPATIC ISCHEMIA/REPERFUSION INJURY; HYPOTHERMIC MACHINE PRESERVATION; RECOMBINANT SUPEROXIDE-DISMUTASE;

D O I：

10.1016/j.transproceed.2013.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ischemia-reperfusion injury (IRI) results in profound allograft damage during liver transplantation. The process of IRI results in adenosine triphosphatase (ATP) depletion, the production of reactive oxygen species, and progressive tissue destruction. This injury process is accelerated on reperfusion in the recipient. Over the last decade an increasing body of literature has identified a complex interplay of molecular and cellular pathways responsible for causing IRI. This article summarizes recent developments, drawing on preclinical and clinical studies, focusing on how the detrimental effects of IRI can be prevented in liver transplantation. We present a balanced overview on how machine preservation technologies, the coagulation system, antioxidants, cytoprotective agents, cytokines, preservation solutions, and the innate and adaptive immune system can be targeted to prevent IRI in liver transplantation.

引用

页码：2083 / 2092

页数：10

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