Novel Approaches to Preventing Ischemia-Reperfusion Injury During Liver Transplantation

被引：43

作者：

Akhtar, M. Z. ^{[1
,2
]}

Henderson, T. ^{[3
]}

Sutherland, A. ^{[2
]}

Vogel, T. ^{[2
]}

Friend, P. J. ^{[1
,2
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Oxford OX3 9DU, England

[2] John Radcliffe Hosp, Oxford Transplant Ctr, Oxford OX3 9DU, England

[3] Univ Oxford, John Radcliffe Hosp, Sch Med, Oxford OX3 9DU, England

来源：

TRANSPLANTATION PROCEEDINGS | 2013年 / 45卷 / 06期

基金：

英国医学研究理事会;

关键词：

HEART-BEATING DONORS; CAROLINA RINSE SOLUTION; SINUSOIDAL ENDOTHELIAL-CELLS; RANDOMIZED CONTROLLED-TRIAL; PLATELET-ACTIVATING-FACTOR; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL PERMEABILITY TRANSITION; HEPATIC ISCHEMIA/REPERFUSION INJURY; HYPOTHERMIC MACHINE PRESERVATION; RECOMBINANT SUPEROXIDE-DISMUTASE;

D O I：

10.1016/j.transproceed.2013.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ischemia-reperfusion injury (IRI) results in profound allograft damage during liver transplantation. The process of IRI results in adenosine triphosphatase (ATP) depletion, the production of reactive oxygen species, and progressive tissue destruction. This injury process is accelerated on reperfusion in the recipient. Over the last decade an increasing body of literature has identified a complex interplay of molecular and cellular pathways responsible for causing IRI. This article summarizes recent developments, drawing on preclinical and clinical studies, focusing on how the detrimental effects of IRI can be prevented in liver transplantation. We present a balanced overview on how machine preservation technologies, the coagulation system, antioxidants, cytoprotective agents, cytokines, preservation solutions, and the innate and adaptive immune system can be targeted to prevent IRI in liver transplantation.

引用

页码：2083 / 2092

页数：10

共 139 条

[1] Role of Endothelial Nitric Oxide Synthase in Remote Ischemic Preconditioning of the Mouse Liver [J].

Abu-Amara, Mahmoud ;

Yang, Shi Yu ;

Quaglia, Alberto ;

Rowley, Peter ;

Fuller, Barry ;

Seifalian, Alexander ;

Davidson, Brian .

LIVER TRANSPLANTATION, 2011, 17 (05) :610-619

[2] ANTIBODIES TO TUMOR-NECROSIS-FACTOR-ALPHA INHIBIT LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY [J].

AKERMAN, P ;

COTE, P ;

YANG, SQ ;

MCCLAIN, C ;

NELSON, S ;

BAGBY, GJ ;

DIEHL, AM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (04) :G579-G585

[3] Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia-reperfusion injury [J].

Argaud, L ;

Gomez, L ;

Gateau-Roesch, O ;

Couture-Lepetit, E ;

Loufouat, J ;

Robert, D ;

Ovize, M .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 39 (06) :893-899

[4] PATHOGENIC ROLE OF KUPFFER CELL ACTIVATION IN THE REPERFUSION INJURY OF COLD-PRESERVED LIVER [J].

ARII, S ;

MONDEN, K ;

ADACHI, Y ;

ZHANG, WH ;

HIGASHITSUJI, H ;

FURUTANI, M ;

MISE, M ;

FUJITA, S ;

NAKAMURA, T ;

IMAMURA, M .

TRANSPLANTATION, 1994, 58 (10) :1072-1077

[5] Glycine rinse protects against liver injury during transplantation [J].

Arora, AS ;

Nichols, JC ;

DeBernardi, M ;

Steers, JL ;

Krom, RAF ;

Gores, GJ .

TRANSPLANTATION PROCEEDINGS, 1999, 31 (1-2) :505-506

[6]

BACHMANN S, 1992, TRANSPLANT INT, V5, P108, DOI 10.1111/j.1432-2277.1992.tb01764.x

[7] Pilot study: Carolina rinse solution improves graft function after orthotopic liver transplantation in humans [J].

Bachmann, S ;

Bechstein, WO ;

Keck, H ;

Lemmens, HP ;

Brandes, N ;

John, AK ;

Lemasters, JJ ;

Neuhaus, P .

TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) :390-392

[8] Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration [J].

Bader, Augustinus ;

Pavlica, Sanja ;

Deiwick, Andrea ;

Lotkova, Halka ;

Kucera, Otto ;

Darsow, Kai ;

Bartel, Sebastian ;

Schulze, Mattes ;

Lange, Harald A. ;

Cervinkova, Zuzana .

LIFE SCIENCES, 2011, 89 (23-24) :827-833

[9]

BAKKER CM, 1993, TRANSPLANTATION, V56, P327

[10] Pilot study on the effect of parenteral vitamin E on ischemia and reperfusion induced liver injury: a double blind, randomized, placebo-controlled trial [J].

Bartels, M ;

Biesatski, HK ;

Engelhart, K ;

Sendlhofer, G ;

Rehak, P ;

Nagel, E .

CLINICAL NUTRITION, 2004, 23 (06) :1360-1370

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