(AAT)n repeat in the cannabinoid receptor gene (CNR1):: association with cocaine addiction in an African-Caribbean population

被引：67
作者：
Ballon, N [1 ]
Leroy, S
Roy, C
Bourdel, MC
Charles-Nicolas, A
Krebs, MO
Poirier, MF
机构：
[1] Univ Hosp Ft De France, Dept Psychiat, BP 632, F-97221 Fort De France, Martinique, France
[2] Univ Paris 05, INSERM, E117, SHU Hop St Anne, Paris, France
来源：
PHARMACOGENOMICS JOURNAL | 2006年 / 6卷 / 02期
关键词：
genetics; crack cocaine; cannabis; substance abuse; schizophrenia; West Indies;
D O I：
10.1038/sj.tpj.6500352
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P < 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P < 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.
引用
收藏
页码：126 / 130
页数：5
相关论文
共 23 条
  • [1] CANNABIS AND SCHIZOPHRENIA - A LONGITUDINAL-STUDY OF SWEDISH CONSCRIPTS
    ANDREASSON, S
    ENGSTROM, A
    ALLEBECK, P
    RYDBERG, U
    [J]. LANCET, 1987, 2 (8574) : 1483 - 1486
  • [2] Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
    Arseneault, L
    Cannon, M
    Poulton, R
    Murray, R
    Caspi, A
    Moffitt, TE
    [J]. BRITISH MEDICAL JOURNAL, 2002, 325 (7374): : 1212 - 1213
  • [3] Causal association between cannabis and psychosis: examination of the evidence
    Arseneault, L
    Cannon, M
    Witton, J
    Murray, RM
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2004, 184 : 110 - 117
  • [4] HLA class I and class II allele and haplotype diversity in Martinicans
    Bera, O
    Cesaire, R
    Quelvennec, E
    Quillivic, F
    de Chavigny, V
    Ribal, C
    Semana, G
    [J]. TISSUE ANTIGENS, 2001, 57 (03): : 200 - 207
  • [5] Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees
    Cao, QH
    Martinez, M
    Zhang, J
    Sanders, AR
    Badner, JA
    Cravchik, A
    Markey, CJ
    Beshah, E
    Guroff, JJ
    Maxwell, ME
    Kazuba, DM
    Whiten, R
    Goldin, LR
    Gershon, ES
    Gejman, PV
    [J]. GENOMICS, 1997, 43 (01) : 1 - 8
  • [6] Cannabinoid receptor gene (CNR1): Association with IV drug use
    Comings, DE
    Muhleman, D
    Gade, R
    Johnson, P
    Verde, R
    Saucier, G
    MacMurray, J
    [J]. MOLECULAR PSYCHIATRY, 1997, 2 (02) : 161 - 168
  • [7] Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence
    Covault, J
    Gelernter, J
    Kranzler, H
    [J]. MOLECULAR PSYCHIATRY, 2001, 6 (05) : 501 - 502
  • [8] A cannabinoid mechanism in relapse to cocaine seeking
    De Vries, TJ
    Shaham, Y
    Homberg, JR
    Crombag, H
    Schuurman, K
    Dieben, J
    Vanderschuren, LJMJ
    Schoffelmeer, ANM
    [J]. NATURE MEDICINE, 2001, 7 (10) : 1151 - 1154
  • [9] DEVANE WA, 1988, MOL PHARMACOL, V34, P605
  • [10] HOEHE MR, 1991, NEW BIOL, V3, P880
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