(AAT)n repeat in the cannabinoid receptor gene (CNR1):: association with cocaine addiction in an African-Caribbean population

被引：67

作者：

Ballon, N ^{[1
]}

Leroy, S

Roy, C

Bourdel, MC

Charles-Nicolas, A

Krebs, MO

Poirier, MF

机构：

[1] Univ Hosp Ft De France, Dept Psychiat, BP 632, F-97221 Fort De France, Martinique, France

[2] Univ Paris 05, INSERM, E117, SHU Hop St Anne, Paris, France

来源：

PHARMACOGENOMICS JOURNAL | 2006年 / 6卷 / 02期

关键词：

genetics; crack cocaine; cannabis; substance abuse; schizophrenia; West Indies;

D O I：

10.1038/sj.tpj.6500352

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P < 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P < 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.

引用

页码：126 / 130

页数：5

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