The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis

被引：29

作者：

Businello, Gianluca ^{[1
]}

Parente, Paola ^{[2
]}

Mastracci, Luca ^{[3
,4
]}

Pennelli, Gianmaria ^{[1
]}

Traverso, Giulia ^{[5
]}

Milione, Massimo ^{[4
]}

Bellan, Elena ^{[1
]}

Michelotto, Mauro ^{[1
]}

Kotsafti, Andromachi ^{[6
]}

Grillo, Federica ^{[3
,4
]}

Fassan, Matteo ^{[1
]}

机构：

[1] Univ Padua, Dept Med DIMED, Surg Pathol Unit, I-35121 Padua, Italy

[2] Fdn IRCCS Osped Casa Sollievo Sofferenza, Pathol Unit, I-71013 San Giovanni Rotondo, FG, Italy

[3] Osped Policlin San Martino IRCCS, Anat Pathol, I-16132 Genoa, Italy

[4] Univ Genoa, Dept Surg Sci & Integrated Diagnost DISC, Anat Pathol, I-16132 Genoa, Italy

[5] Veneto Inst Oncol IOV IRCCS, I-35128 Padua, Italy

[6] Veneto Inst Oncol IOV IRCCS, Lab Adv Translat Res, I-35128 Padua, Italy

来源：

CANCERS | 2020年 / 12卷 / 08期

关键词：

esophageal cancer; squamous cell carcinoma; biomarkers; molecular landscape; carcinogenesis; CPG ISLAND HYPERMETHYLATION; GROWTH-FACTOR RECEPTOR; POOR-PROGNOSIS; GENOMIC CHARACTERIZATION; ABERRANT METHYLATION; DNA METHYLATION; LINE-1; HYPOMETHYLATION; GENE HYPERMETHYLATION; PROMOTER METHYLATION; HUMAN-PAPILLOMAVIRUS;

D O I：

10.3390/cancers12082160

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.

引用

页码：1 / 19

页数：20

共 132 条

[1] Epidemiology of Esophageal Squamous Cell Carcinoma [J].

Abnet, Christian C. ;

Arnold, Melina ;

Wei, Wen-Qiang .

GASTROENTEROLOGY, 2018, 154 (02) :360-373

[2] Promoter Methylation in Cytology Specimens as an Early Detection Marker for Esophageal Squamous Dysplasia and Early Esophageal Squamous Cell Carcinoma [J].

Adams, Lisa ;

Roth, Mark J. ;

Abnet, Christian C. ;

Dawsey, Sonja P. ;

Qiao, You-Lin ;

Wang, Guo-Qing ;

Wei, Wen-Qiang ;

Lu, Ning ;

Dawsey, Sanford M. ;

Woodson, Karen .

CANCER PREVENTION RESEARCH, 2008, 1 (05) :357-361

[3] Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma [J].

Agrawal, Nishant ;

Jiao, Yuchen ;

Bettegowda, Chetan ;

Hutfless, Susan M. ;

Wang, Yuxuan ;

David, Stefan ;

Cheng, Yulan ;

Twaddell, William S. ;

Latt, Nyan L. ;

Shin, Eun J. ;

Wang, Li-Dong ;

Wang, Liang ;

Yang, Wancai ;

Velculescu, Victor E. ;

Vogelstein, Bert ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. ;

Meltzer, Stephen J. .

CANCER DISCOVERY, 2012, 2 (10) :899-905

[4]

Ahmed Kabir, 2013, Case Rep Gastroenterol, V7, P498, DOI 10.1159/000357303

[5] Chewing areca nut, betel quid, oral snuff, cigarette smoking and the risk of oesophageal squamous-cell carcinoma in South Asians: A multicentre case-control study [J].

Akhtar, Saeed ;

Sheikh, Adnan A. ;

Qureshi, Hammad U. .

EUROPEAN JOURNAL OF CANCER, 2012, 48 (05) :655-661

[6] Deciphering Signatures of Mutational Processes Operative in Human Cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Campbell, Peter J. ;

Stratton, Michael R. .

CELL REPORTS, 2013, 3 (01) :246-259

[7] Clinical update on head and neck cancer: molecular biology and ongoing challenges [J].

Alsahafi, Elham ;

Begg, Katheryn ;

Amelio, Ivano ;

Raulf, Nina ;

Lucarelli, Philippe ;

Sauter, Thomas ;

Tavassoli, Mahvash .

CELL DEATH & DISEASE, 2019, 10 (8)

[8] Global incidence of oesophageal cancer by histological subtype in 2012 [J].

Arnold, Melina ;

Soerjomataram, Isabelle ;

Ferlay, Jacques ;

Forman, David .

GUT, 2015, 64 (03) :381-387

[9] LINE-1 Hypomethylation, DNA Copy Number Alterations, and CDK6 Amplification in Esophageal Squamous Cell Carcinoma [J].

Baba, Yoshifumi ;

Watanabe, Masayuki ;

Murata, Asuka ;

Shigaki, Hironobu ;

Miyake, Keisuke ;

Ishimoto, Takatsugu ;

Iwatsuki, Masaaki ;

Iwagami, Shiro ;

Yoshida, Naoya ;

Oki, Eiji ;

Sakamaki, Kentaro ;

Nakao, Mitsuyoshi ;

Baba, Hideo .

CLINICAL CANCER RESEARCH, 2014, 20 (05) :1114-1124

[10] A review of the alterations in DNA methylation in esophageal squamous cell carcinoma [J].

Baba, Yoshifumi ;

Watanabe, Masayuki ;

Baba, Hideo .

SURGERY TODAY, 2013, 43 (12) :1355-1364

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