Nonoparticles of biodegradable polymers for new-concept chemotherapy

被引：153
作者：
Feng, SS
机构：
[1] Natl Univ Singapore, Fac Engn, Dept Environm Chem & Engn, Singapore 119260, Singapore
[2] Natl Univ Singapore, Fac Engn, Dept Bioengn, Singapore 119260, Singapore
来源：
EXPERT REVIEW OF MEDICAL DEVICES | 2004年 / 1卷 / 01期
关键词：
anticancer drugs; biomaterials; blood-brain barrier; cancer; chemothetapeutic engineering; controlled release; drug delivery; oral chemotherapy; paclitaxel; targeted delivery;
D O I：
10.1586/17434440.1.1.115
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The current regimen of chemotherapy is for from satisfactory - its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under Intensive Investigation In the past few decades In attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments In nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.
引用
收藏
页码：115 / 125
页数：11
相关论文
共 82 条
[1]   Clinical aspects of drug delivery to tumors [J].
Au, JLS ;
Jang, SH ;
Wientjes, MG .
JOURNAL OF CONTROLLED RELEASE, 2002, 78 (1-3) :81-95
[2]   Determinants of drug delivery and transport to solid tumors [J].
Au, JLS ;
Jang, SH ;
Zheng, J ;
Chen, CT ;
Song, S ;
Hu, L ;
Wientjes, MG .
JOURNAL OF CONTROLLED RELEASE, 2001, 74 (1-3) :31-46
[3]   Poly n-butyl cyanoacrylate nanoparticles:: a mechanistic study of polymerisation and particle formation [J].
Behan, N ;
Birkinshaw, C ;
Clarke, N .
BIOMATERIALS, 2001, 22 (11) :1335-1344
[4]   Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport [J].
Behrens, I ;
Pena, AIV ;
Alonso, MJ ;
Kissel, T .
PHARMACEUTICAL RESEARCH, 2002, 19 (08) :1185-1193
[5]   Nanoparticles in cancer therapy and diagnosis [J].
Brigger, I ;
Dubernet, C ;
Couvreur, P .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651
[6]   In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel [J].
Chen, DB ;
Yang, TZ ;
Lu, WL ;
Zhang, Q .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (11) :1444-1447
[7]  
Chorny M, 2000, CRIT REV THER DRUG, V17, P249
[8]   Preparation of avidin-labelled gelatin nanoparticles as carriers for biotinylated peptide nucleic acid (PNA) [J].
Coester, C ;
Kreuter, J ;
von Briesen, H ;
Langer, K .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 196 (02) :147-149
[9]   POLYCYANOACRYLATE NANOCAPSULES AS POTENTIAL LYSOSOMOTROPIC CARRIERS - PREPARATION, MORPHOLOGICAL AND SORPTIVE PROPERTIES [J].
COUVREUR, P ;
KANTE, B ;
ROLAND, M ;
GUIOT, P ;
BAUDUIN, P ;
SPEISER, P .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (05) :331-332
[10]  
Das GS, 2001, J BIOMED MATER RES, V55, P96, DOI 10.1002/1097-4636(200104)55:1<96::AID-JBM130>3.3.CO
123456789