Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

被引：54

作者：

Li, Xiang ^{[1
,2
]}

Tian, Ye ^{[1
]}

Yang, Sheng-xiang ^{[1
]}

Zhang, Ya-mei ^{[1
]}

Qin, Jian-chun ^{[1
]}

机构：

[1] Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Azaphilone; Chaetomugilide; Cytotoxicity; Chaetomium globosum;

D O I：

10.1016/j.bmcl.2013.03.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three novel azaphilone alkaloids, namely chaetomugilides A-C (1-3), together with three related compounds (4-6) were isolated from the methanol extract of Chaetomium globosum TY1, an endophytic fungus isolated from Ginkgo biloba. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. The isolated compounds exhibited highly cytotoxic activities against human cancer cell line HePG2 with the IC50 values range from 1.7 to 53.4 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2945 / 2947

页数：3

共 9 条

[1] Bioactive natural products from the endophytic fungus Ascochyta sp from Meliotus dentatus -: Configurational assignment by solid-state CD and TDDFT calculations [J].

Krohn, Karsten ;

Kock, Ines ;

Elsaesser, Brigitta ;

Floerke, Ulrich ;

Schulz, Barbara ;

Draeger, Siegfried ;

Pescitelli, Gennaro ;

Antus, Sandor ;

Kurtan, Tibor .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 2007 (07) :1123-1129

[2] Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05 [J].

Phonkerd, Nutchanat ;

Kanokmedhakul, Somdej ;

Kanokmedhakul, Kwanjai ;

Soytong, Kasem ;

Prabpai, Samran ;

Kongsearee, Palangpon .

TETRAHEDRON, 2008, 64 (40) :9636-9645

[3]

Qin JC, 2009, NAT PROD COMMUN, V4, P1473

[4] Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba [J].

Qin, Jian-Chun ;

Gao, Jin-Ming ;

Zhang, Ya-Mei ;

Yang, Sheng-Xiang ;

Bai, Ming-Sheng ;

Ma, Ya-Tuan ;

Laatsch, Hartmut .

STEROIDS, 2009, 74 (09) :786-790

[5] Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba [J].

Qin, Jian-Chun ;

Zhang, Ya-Mei ;

Gao, Jin-Ming ;

Bai, Ming-Sheng ;

Yang, Sheng-Xiang ;

Laatsch, Hartmut ;

Zhang, An-Ling .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) :1572-1574

[6]

Saikkonen K, 2004, TRENDS PLANT SCI, V9, P275, DOI 10.1016/j.tplants.2004.04.005

[7] Natural products from endophytic microorganisms [J].

Strobel, G ;

Daisy, B ;

Castillo, U ;

Harper, J .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (02) :257-268

[8] Rainforest endophytes and bioactive products [J].

Strobel, GA .

CRITICAL REVIEWS IN BIOTECHNOLOGY, 2002, 22 (04) :315-333

[9] Metabolites from an Endophytic Fungus Sphaceloma sp LN-15 Isolated from the Leaves of Melia azedarach [J].

Zhang, An-Ling ;

He, Li-Ying ;

Gao, Jin-Ming ;

Xu, Xu ;

Li, Shi-Qing ;

Bai, Ming-Sheng ;

Qin, Jian-Chun .

LIPIDS, 2009, 44 (08) :745-751

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