Therapeutic inhibition of Hedgehog-GLI signaling in cancer: Epithelial, stromal, or stem cell targets?

被引：54
作者：
Altaba, Ariel Ruiz I. [1 ]
机构：
[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
来源：
CANCER CELL | 2008年 / 14卷 / 04期
关键词：
D O I：
10.1016/j.ccr.2008.09.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk prolifertion that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLl signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.
引用
收藏
页码：281 / 283
页数：3
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