Effect of achiral medium on chiral discrimination of pyrrolidin-2-one derivatives on a cyclodextrin column

被引：0
|
作者：
Gorska, Magdalena [1 ,2 ]
Bielejewska, Anna [2 ]
Kulig, Katarzyna [3 ]
Les, Andrzej [1 ,4 ]
Widomski, Pawel [2 ]
Zukowski, Janusz
机构：
[1] Inst Farmaceutyczny, PL-01793 Warsaw, Poland
[2] Inst Chem Fizycznej PAN, Warsaw, Poland
[3] Uniwersytet Jagiellonski, Coll Med, Krakow, Poland
[4] Uniwersytet Warszawski, Warsaw, Poland
来源：
PRZEMYSL CHEMICZNY | 2012年 / 91卷 / 09期
关键词：
STATIONARY-PHASE; LIQUID-CHROMATOGRAPHY; PHOSPHINE OXIDES; MOBILE-PHASE; SEPARATION; ENANTIOMERS; RECOGNITION; RESOLUTION; SELECTION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fifteen racemic derivatives of pyrrolidin-2-one were sepd. on a tri(3,5-dimethylphenylcarboilo)-beta-cyclodextrin column by using n-hexane/EtOH or n-hexane/Me2CHOH in normal mobile phases, H2O/MeCN reversed phases and MeCN/AcOH or MeCN/AcOH/Et3N org. phases. EtOH was more efficient than Me2CHOH in normal phases. The addn. of Et3N resulted in an improvement of sepn. in reversed phase, where the best results were achieved at pH 3.
引用
收藏
页码：1834 / 1841
页数：8
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