Interrelation between ROS and Ca2+ in aging and age-related diseases

被引:221
作者
Madreiter-Sokolowski, Corina T. [1 ,2 ]
Thomas, Carolin [1 ]
Ristow, Michael [1 ]
机构
[1] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Translat Med, Energy Metab Lab, Zurich, Switzerland
[2] Austrian Sci Fund FWF, Vienna, Austria
来源
REDOX BIOLOGY | 2020年 / 36卷
基金
瑞士国家科学基金会;
关键词
Aging; ROS homeostasis; Ca2+ homeostasis; Cardiovascular diseases; Type 2 diabetes mellitus; Neurodegenerative diseases; Malignant diseases; SARCOPLASMIC-RETICULUM CA2+-ATPASE; MITOCHONDRIAL CALCIUM UNIPORTER; PROTEIN S-GLUTATHIONYLATION; OXYGEN SPECIES ROS; OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; NADPH OXIDASES; LIFE-SPAN; RYANODINE RECEPTOR; SERCA CYSTEINE-674;
D O I
10.1016/j.redox.2020.101678
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca2+ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by various production sites within the cell. Ca2+ controls membrane potential, modulates mitochondrial adenosine triphosphate (ATP) production and affects proteins like calcineurin (CaN) or calmodulin (CaM), which, in turn, have a wide area of action. Overwhelming Ca2+ levels within mitochondria efficiently induce and trigger cell death. In contrast, ROS comprise a diverse group of relatively unstable molecules with an odd number of electrons that abstract electrons from other molecules to gain stability. Depending on the type and produced amount, ROS act either as signaling molecules by affecting target proteins or as harmful oxidative stressors by damaging cellular components. Due to their wide range of actions, it is little wonder that Ca2+ and ROS signaling pathways overlap and impact one another. Growing evidence suggests a crucial implication of this mutual interplay on the development and enhancement of age-related disorders, including cardiovascular and neurodegenerative diseases as well as cancer.
引用
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页数:12
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