5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis

被引：102
作者：
Upcroft, JA
Dunn, LA
Wright, JM
Benakli, K
Upcroft, P
Vanelle, P
机构：
[1] Queensland Inst Med Res, Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
[2] ACITHN, Brisbane, Qld 4029, Australia
[3] Univ Queensland, Sch Populat Hlth, Brisbane, Qld 4072, Australia
[4] Univ Mediterranee, CNRS, UMR 6517, LCOP,Fac Pharm, F-31185 Marseille 05, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期
关键词：
D O I：
10.1128/AAC.50.1.344-347.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.
引用
收藏
页码：344 / 347
页数：4
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