Excretion of enrofloxacin in pigs and its effect on ecological environment

被引：42

作者：

Zhou, Xiujin ^{[1
]}

Chen, Chaoxi ^{[1
]}

Yue, Lei ^{[1
]}

Sun, Yongxue ^{[1
]}

Ding, Huanzhong ^{[1
]}

Liu, Yahong ^{[1
]}

机构：

[1] S China Agr Univ, Guang Dong Prov Key Lab Vet Pharmaceut Dev & Safe, Guangzhou, Guangdong, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2008年 / 26卷 / 03期

关键词：

Ammonification; Ecological environment; HPLC (high performance liquid chromatography); MIC (minimal inhibitory concentration); Nitrification; Safety evaluation;

D O I：

10.1016/j.etap.2008.04.004

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The concentration of enrofloxacin and its metabolite, ciprofloxacin, in feces and urines were investigated in healthy pigs after oral administration (p.o.) of a single dose of 5.0 mg/kg bw and an indoor soil model was set to study the effects of enrofloxacin and ciprofloxacin through biological and chemical metrics including changes to edaphon, edaphic ammonification and nitrification and the soil bacterial community. The results showed that the concentrations of entofloxacin and ciprofloxacin in feces and urines fluctuated, the maximum concentrations of enrofloxacin and ciprofloxacin in the urine were 22.74 and 48.04 mu g/ml, respectively, 24.68 and 30.98 mu g/g in the feces, respectively. The effect of enrofloxacin and ciprofloxacin on edaphon, edaphic ammonification and nitrification and the soil bacterial community differed at different time points. And the model can be used to evaluate environmental safety of enrofloxacin and develop possible procedures for the safe handling and utilization of animal excrement. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：272 / 277

页数：6

共 10 条

[1] Fluoroquinolones in animal health [J].