TGF-beta1 on osteoimmunology and the bone component cells

被引：92
作者：
Kasagi, Shimpei [1 ]
Chen, Wanjun [1 ]
机构：
[1] NIDCR, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA
来源：
CELL AND BIOSCIENCE | 2013年 / 3卷
关键词：
GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; TUMOR-NECROSIS-FACTOR; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; RHEUMATOID-ARTHRITIS; CROSS-TALK; 1,25-DIHYDROXYVITAMIN D-3; MORPHOGENETIC PROTEIN-2; PARATHYROID-HORMONE;
D O I：
10.1186/2045-3701-3-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta 1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-beta 1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-beta 1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.
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页数：7
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