Supercritical fluid micronization of risperidone pharmaceutical substance

被引：17

作者：

Bagratashvili, V. N. ^{[1
]}

Egorov, A. M. ^{[2
]}

Krotova, L. I. ^{[1
]}

Mironov, A. V. ^{[1
]}

Panchenko, V. Ya. ^{[1
]}

Parenago, O. O. ^{[3
]}

Popov, V. K. ^{[1
]}

Revelsky, I. A. ^{[4
]}

Timashev, P. S. ^{[1
]}

Tsypina, S. I. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Laser & Informat Technol, Troitsk, Moscow Oblast, Russia

[2] ZAO Rafarma, Moscow, Russia

[3] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow, Russia

[4] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B | 2012年 / 6卷 / 07期

关键词：

SCF micronization; risperidone; polymorphism; ASSISTED ATOMIZATION; DRUG PARTICLES; IBUPROFEN;

D O I：

10.1134/S1990793112070019

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

A comparative study of the supercritical fluid micronization of risperidone pharmaceutical substance with an initial particle size of 50 to 100 mu m by the RESS and SAS methods aimed at increasing the bioavailability of risperidone as a drug was performed. Both methods makes it possible to prepare risperidone particle of various forms, 5-20 mu m in size. However, the SAS method is preferable, because in contrast to RESS, it does not cause contamination of risperidone with organic solvents used in both processes or any other impurities and also makes it possible to vary the shape and size of particles. It is shown that, during SAS micronization, the polymorphic form of risperidone changes from triclinic to monoclinic.

引用

页码：804 / 812

页数：9

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