The genetics of osteoporosis

被引:7
作者
Roux, S [1 ]
机构
[1] CHU Bicetre, Rhumatol Dept, F-94275 Le Kremlin Bicetre, France
关键词
collagen type I; genetic; osteoporosis; polymorphism; VDR;
D O I
10.1016/S1297-319X(01)00311-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A genetic component clearly contributes to bone mass determination by influencing peak bone mass acquisition or, to a lesser degree, bone loss later in life. The analysis of genetic markers for osteoporosis is complex because multiple genes are involved and because osteoporosis is a multifactorial disease. The influence of a number of candidate gene alleles on bone mass has been studied in various populations. Results have been inconsistent and, at times, contradictory, as illustrated by studies on the vitamin D receptor gene. The most conclusive finding is the association linking the Sp1 polymorphism of type 1 collagen to bone mineral density and osteoporotic fractures, Polymorphisms of other genes either have very little influence or remain unexplored. In all likelihood, the best predictive value will be obtained by using a combination of several gene polymorphisms. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:482 / 486
页数:5
相关论文
共 34 条
[1]  
Arden NK, 1996, J BONE MINER RES, V11, P530
[2]   Transforming growth factor-β1 gene polymorphism, bone turnover, and bone mass in Italian postmenopausal women [J].
Bertoldo, F ;
D'Agruma, L ;
Furlan, F ;
Colapietro, F ;
Lorenzi, MT ;
Maioran, N ;
Iolascon, A ;
Zelante, L ;
Locascio, V ;
Gasparini, P .
JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (04) :634-639
[3]  
Cooper GS, 1996, J BONE MINER RES, V11, P1841
[4]   Familial resemblance of bone mineral density (BMD) and calcaneal ultrasound attenuation: The BMD in mothers and daughters study [J].
Danielson, ME ;
Cauley, JA ;
Baker, CE ;
Newman, AB ;
Dorman, JS ;
Towers, JD ;
Kuller, LH .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (01) :102-110
[5]   A novel polymorphism in the promoter region for the human osteocalcin gene: The possibility of a correlation with bone mineral density in postmenopausal Japanese women [J].
Dohi, Y ;
Iki, M ;
Ohgushi, H ;
Gojo, S ;
Tabata, S ;
Kajita, E ;
Nishino, H ;
Yonemasu, K .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (10) :1633-1639
[6]   Suggestive linkage of the parathyroid receptor type 1 to osteoporosis [J].
Duncan, EL ;
Brown, MA ;
Sinsheimer, J ;
Bell, J ;
Carr, AJ ;
Wordsworth, BP ;
Wass, JAH .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (12) :1993-1999
[7]   Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: The OFELY study [J].
Eccleshall, TR ;
Garnero, P ;
Gross, C ;
Delmas, PD ;
Feldman, D .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (01) :31-35
[8]   Vitamin D receptor gene polymorphisms and the risk of fractures in older women [J].
Ensrud, KE ;
Stone, K ;
Cauley, JA ;
White, C ;
Zmuda, JM ;
Nguyen, TV ;
Eisman, JA ;
Cummings, SR .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (10) :1637-1645
[9]   Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density:: Interaction with age, dietary calcium, and 3′-end region polymorphisms [J].
Ferrari, S ;
Rizzoli, R ;
Manen, D ;
Slosman, D ;
Bonjour, JP .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (06) :925-930
[10]   Genetic influence on bone turnover in postmenopausal twins [J].
Garnero, P ;
Arden, NK ;
Griffiths, G ;
Delmas, PD ;
Spector, TD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (01) :140-146