The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease

被引:85
作者
Vacante, Francesca [1 ]
Denby, Laura [1 ]
Sluimer, Judith C. [1 ,2 ]
Baker, Andrew H. [1 ]
机构
[1] Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Maastricht Univ, Med Ctr, Dept Pathol, NL-6229 HX Maastricht, Netherlands
基金
欧洲研究理事会;
关键词
LONG NONCODING RNAS; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS; MICRORNA; EXPRESSION; BIOGENESIS; PHENOTYPE; SIGNATURE; GENOMICS; MICROVESICLES;
D O I
10.1016/j.vph.2018.11.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical modulators of phenotypic changes associated with physiological and pathological contexts in a variety of cardiovascular diseases (CVDs). Although it has been well established that hereditable genetic alterations and exposure to risk factors are crucial in the development of CVDs, other critical regulators of cell function impact on disease processes. Here we discuss noncoding RNAs have only recently been identified as key players involved in the progression of disease. In particular, we discuss micro RNA (miR)-143/145 since they represent one of the most characterised microRNA clusters regulating smooth muscle cell (SMC) differentiation and phenotypic switch in response to vascular injury and remodelling. MiR143HG is a well conserved long noncoding RNA (lncRNA), which is the host gene for miR-143/145 and recently implicated in cardiac specification during heart development. Although the lncRNA-miRNA interactions have not been completely characterised, their crosstalk is now beginning to emerge and likely requires further research focus. In this review we give an overview of the biology of the genomic axis that is miR-143/145 and MiR143HG, focusing on their important functional role(s) in the cardiovascular system.
引用
收藏
页码:24 / 30
页数:7
相关论文
共 76 条
[1]   The eukaryotic genome as an RNA machine [J].
Amaral, Paulo P. ;
Dinger, Marcel E. ;
Mercer, Tim R. ;
Mattick, John S. .
SCIENCE, 2008, 319 (5871) :1787-1789
[2]   Emerging evidence for functional peptides encoded by short open reading frames [J].
Andrews, Shea J. ;
Rothnagel, Joseph A. .
NATURE REVIEWS GENETICS, 2014, 15 (03) :193-204
[3]   lncRNA/MicroRNA Interactions in the Vasculature [J].
Ballantyne, M. D. ;
McDonald, R. A. ;
Baker, A. H. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2016, 99 (05) :494-501
[4]   Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster [J].
Boettger, Thomas ;
Beetz, Nadine ;
Kostin, Sawa ;
Schneider, Johanna ;
Krueger, Marcus ;
Hein, Lutz ;
Braun, Thomas .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2634-2647
[5]   Long Noncoding RNAs From Clinical Genetics to Therapeutic Targets? [J].
Boon, Reinier A. ;
Jae, Nicolas ;
Holdt, Lesca ;
Dimmeler, Stefanie .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (10) :1214-1226
[6]   The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells [J].
Boucher, Joshua M. ;
Peterson, Sarah M. ;
Urs, Sumithra ;
Zhang, Chunxiang ;
Liaw, Lucy .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (32) :28312-28321
[7]   Circulating microparticles - A potential prognostic marker for atherosclerotic vascular disease [J].
Boulanger, Chantal M. ;
Amabile, Nicolas ;
Tedgui, Alain .
HYPERTENSION, 2006, 48 (02) :180-186
[8]   Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk [J].
Burd, Christin E. ;
Jeck, William R. ;
Liu, Yan ;
Sanoff, Hanna K. ;
Wang, Zefeng ;
Sharpless, Norman E. .
PLOS GENETICS, 2010, 6 (12) :1-15
[9]   The transcriptional landscape of the mammalian genome [J].
Carninci, P ;
Kasukawa, T ;
Katayama, S ;
Gough, J ;
Frith, MC ;
Maeda, N ;
Oyama, R ;
Ravasi, T ;
Lenhard, B ;
Wells, C ;
Kodzius, R ;
Shimokawa, K ;
Bajic, VB ;
Brenner, SE ;
Batalov, S ;
Forrest, ARR ;
Zavolan, M ;
Davis, MJ ;
Wilming, LG ;
Aidinis, V ;
Allen, JE ;
Ambesi-Impiombato, X ;
Apweiler, R ;
Aturaliya, RN ;
Bailey, TL ;
Bansal, M ;
Baxter, L ;
Beisel, KW ;
Bersano, T ;
Bono, H ;
Chalk, AM ;
Chiu, KP ;
Choudhary, V ;
Christoffels, A ;
Clutterbuck, DR ;
Crowe, ML ;
Dalla, E ;
Dalrymple, BP ;
de Bono, B ;
Della Gatta, G ;
di Bernardo, D ;
Down, T ;
Engstrom, P ;
Fagiolini, M ;
Faulkner, G ;
Fletcher, CF ;
Fukushima, T ;
Furuno, M ;
Futaki, S ;
Gariboldi, M .
SCIENCE, 2005, 309 (5740) :1559-1563
[10]   A Role for miR-145 in Pulmonary Arterial Hypertension Evidence From Mouse Models and Patient Samples [J].
Caruso, Paola ;
Dempsie, Yvonne ;
Stevens, Hannah C. ;
McDonald, Robert A. ;
Long, Lu ;
Lu, Ruifang ;
White, Kevin ;
Mair, Kirsty M. ;
McClure, John D. ;
Southwood, Mark ;
Upton, Paul ;
Xin, Mei ;
van Rooij, Eva ;
Olson, Eric N. ;
Morrell, Nicholas W. ;
MacLean, Margaret R. ;
Baker, Andrew H. .
CIRCULATION RESEARCH, 2012, 111 (03) :290-300