Airway delivery of peptides and proteins using nanoparticles

被引：50

作者：

Dombu, Christophe Y. ^{[2
]}

Betbeder, Didier ^{[1
,2
,3
]}

机构：

[1] Univ Lille 2, Fac Med Pole Rech, IFR 114, IMPRT,EA4483, F-59000 Lille, France

[2] PRES Univ Lille Nord France, Lille, France

[3] Univ Artois, F-62030 Arras, France

来源：

BIOMATERIALS | 2013年 / 34卷 / 02期

关键词：

Nanoparticles; Airway; Peptide; Protein; N-TRIMETHYL CHITOSAN; DRUG-DELIVERY; IN-VITRO; INTRANASAL IMMUNIZATION; NASAL ABSORPTION; PULMONARY DELIVERY; GROWTH-FACTOR; MUCOCILIARY CLEARANCE; COATED NANOPARTICLES; THERAPEUTIC PROTEINS;

D O I：

10.1016/j.biomaterials.2012.08.070

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Delivery of peptides and proteins via the airways is one of the most exciting potential applications of nanomedicine. These macromolecules could be used for many therapeutic applications, however due to their poor stability in physiological medium and difficulties in delivering them across biological barriers, they are very difficult to use in therapy. Nanoparticulate drug delivery systems have emerged as one of the most promising technologies to overcome these limitations, owing mainly to their proven capacity to cross biological barriers and to enter cells in high yields, thus improving delivery of macromolecules. In this review, we summarize the current advances in nanoparticle designed for transmucosal delivery of peptides and proteins. Challenges that must be overcome in order to derive clinical benefits are also discussed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：516 / 525

页数：10

共 155 条

[1]

Agu RU, 2001, RESP RES, V2, P198

[2] Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives [J].

Akagi, Takami ;

Wang, Xin ;

Uto, Tomofumi ;

Baba, Masanori ;

Akashi, Mitsuru .

BIOMATERIALS, 2007, 28 (23) :3427-3436

[3] Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations [J].

Al-Qadi, S. ;

Grenha, A. ;

Carrion-Recio, D. ;

Seijo, B. ;

Remunan-Lopez, C. .

JOURNAL OF CONTROLLED RELEASE, 2012, 157 (03) :383-390

[4] Solid lipid nanoparticles as a drug delivery system for peptides and proteins [J].

Almeida, Antonio J. ;

Souto, Eliana .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) :478-490

[5] N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination:: Biological properties and immunogenicity in a mouse model [J].

Amidi, Maryam ;

Romeijn, Stefan G. ;

Verhoef, J. Coos ;

Junginger, Hans E. ;

Bungener, Laura ;

Huckriede, Anke ;

Crommelin, Daan J. A. ;

Jiskoot, Wim .

VACCINE, 2007, 25 (01) :144-153

[6] The success and failure of BCG - implications for a novel tuberculosis vaccine [J].

Andersen, P ;

Doherty, TM .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (08) :656-662

[7] Self-assembled cationic nanogels for intracellular protein delivery [J].

Ayame, Hirohito ;

Morimoto, Nobuyuki ;

Akiyoshi, Kazunari .

BIOCONJUGATE CHEMISTRY, 2008, 19 (04) :882-890

[8]

AYERS MM, 1988, EUR RESPIR J, V1, P58

[9] Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis [J].

Ballester, Marie ;

Nembrini, Chiara ;

Dhar, Neeraj ;

de Titta, Alexandre ;

de Piano, Cyntia ;

Pasquier, Miriella ;

Simeoni, Eleonora ;

van der Vlies, Andre J. ;

McKinney, John D. ;

Hubbell, Jeffrey A. ;

Swartz, Melody A. .

VACCINE, 2011, 29 (40) :6959-6966

[10] Sampling Conventions for Estimating Ultrafine and Fine Aerosol Particle Deposition in the Human Respiratory Tract [J].

Bartley, David L. ;

Vincent, James H. .

ANNALS OF OCCUPATIONAL HYGIENE, 2011, 55 (07) :696-709

← 1 2 3 4 5 6 7 8 9 10 →