Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique

被引：27
作者：
Harada, T
Katada, J
Tachiki, A
Asari, T
Iijima, K
Uno, I
Ojima, I
Hayashi, Y
机构：
[1] NIPPON STEEL CORP LTD, ADV MAT & TECHNOL RES LABS, LIFE SCI RES CTR, KAWASAKI, KANAGAWA 211, JAPAN
[2] SUNY STONY BROOK, DEPT CHEM, STONY BROOK, NY 11794 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(96)00610-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM. (C) 1997, Elsevier Science Ltd.
引用
收藏
页码：209 / 212
页数：4
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