Hepatocyte-like cells derived from induced pluripotent stem cells: A versatile tool to understand lipid disorders

被引：6
|
作者：
Larsen, Lars E. [1 ]
Smith, Mikhaila A. [2 ,3 ]
Abbey, Deepti [2 ,3 ]
Korn, Amber [1 ,4 ]
Reeskamp, Laurens F. [1 ,4 ]
Hand, Nicholas J. [2 ,3 ]
Holleboom, Adriaan G. [1 ,4 ]
机构：
[1] Acad Med Ctr, Dept Expt Vasc Med, Amsterdam, Netherlands
[2] Univ Penn, Perelman Sch Med, Dept Genet, 3400 Civ Ctr Blvd,Smilow Bldg,SCTR 11-135, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
[4] Acad Med Ctr, Dept Vasc Med, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands
来源：
ATHEROSCLEROSIS | 2020年 / 303卷
关键词：
Dyslipidemias; Liver organoids; Regenerative medicine; Drug testing; Non-alcohol fatty liver disease; TRIGLYCERIDE TRANSFER PROTEIN; HEPATIC STELLATE CELLS; FATTY LIVER-DISEASE; SCAVENGER RECEPTOR; CARDIOVASCULAR RISK; APOLIPOPROTEIN-B; CRE RECOMBINASE; CHIMERIC MICE; HEPG2; CELLS; DNA-DAMAGE;
D O I：
10.1016/j.atherosclerosis.2020.03.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Dyslipidemias are strongly linked to the development of atherosclerotic cardiovascular disease. Most dyslipi- demias find their origin in the liver. In recent years, the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells has provided a versatile platform for the functional study of various dyslipidemias, both rare genetic dyslipidemia as well as common lipid disorders associated with insulin resistance or non- alcoholic fatty liver disease. In addition, iPSC-derived hepatocytes can serve as a cell model for developing novel lipid lowering therapies and have the potential of regenerative medicine. This review provides an overview of these developments.
引用
收藏
页码：8 / 14
页数：7
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