Electrodiffusion of ions inside living cells

被引:6
作者
Choi, YS [1 ]
Resasco, D
Schaff, J
Slepchenko, B
机构
[1] Univ Connecticut, Dept Math, Storrs, CT 06269 USA
[2] Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA
[3] Univ Connecticut, Ctr Hlth, Ctr Biomed Imaging Technol, Dept Biochem & Physiol, Farmington, CT 06030 USA
关键词
D O I
10.1093/imamat/62.3.207
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Electrodiffusion of ions, both inside and outside biological cells, are of utmost importance to proper cellular functions. Experiments indicate that both ion concentrations and electropotential can jump discontinuously across the cell membranes. We study a system of nonlinear partial differential equations modelling such phenomena. Jump conditions for species concentrations and electropotential across cell membranes are imposed. Under zero-flux boundary conditions for one-dimensional domains, the solutions are proved to exist for all times. With further assumptions, these transient solutions will converge to the unique steady-state solution. Numerical experiments in one- and two-dimensional domains are also performed in order to study some unresolved theoretical issues.
引用
收藏
页码:207 / 226
页数:20
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