Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations

被引：10
作者：
Huang, Ping [1 ,3 ]
Yu, Shouyi [2 ]
Wu, Changyou [4 ]
Liang, Lijun [1 ,3 ]
机构：
[1] Guangdong Prov Ctr Dis Control & Prevent, Key Lab Emergency Pathogen Detect, Guangzhou 511430, Guangdong, Peoples R China
[2] Southern Med Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Epidemiol, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Inst Immunol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2013年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Influenza; H1N1; Epitope; Vaccine; Immunoinformatic; VIRUSES; PROTECTION; EMERGENCE; IMMUNITY;
D O I：
10.1186/1479-5876-11-47
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immunity between 2009 pandemic H1N1 (pH1N1) and seasonal H1N1 (sH1N1) viruses. It was found that in sH1N1 viruses, 29 epitope regions of HA genes and 8 epitope regions of NA genes which had been experimentally identified, were highly conserved (97.1-100.0%) in the corresponding genes and predictive epitopes of the pH1N1 viruses. The results suggested that highly conserved antigenic epitope regions might act as the basis of common antigenic vaccines against pH1N1 and sH1N1 viruses.
引用
收藏
页数：8
相关论文
共 20 条
  • [11] The emergence of novel swine influenza viruses in North America
    Olsen, CW
    [J]. VIRUS RESEARCH, 2002, 85 (02) : 199 - 210
  • [12] Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses
    Pica, Natalie
    Hai, Rong
    Krammer, Florian
    Wang, Taia T.
    Maamary, Jad
    Eggink, Dirk
    Tan, Gene S.
    Krause, Jens C.
    Moran, Thomas
    Stein, Cheryl R.
    Banach, David
    Wrammert, Jens
    Belshe, Robert B.
    Garcia-Sastre, Adolfo
    Palese, Peter
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (07) : 2573 - 2578
  • [13] Saha Sudipto, 2007, V409, P387, DOI 10.1007/978-1-60327-118-9_29
  • [14] Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4+ T cells against the swine-origin H1N1 influenza virus
    Schanen, Brian C.
    De Groot, Anne S.
    Moise, L.
    Ardito, Matt
    McClaine, Elizabeth
    Martin, William
    Wittman, Vaughan
    Warren, William L.
    Drake, Donald R., III
    [J]. VACCINE, 2011, 29 (17) : 3299 - 3309
  • [15] Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma
    Strothmeyer, Anna-Maria
    Papaioannou, Dimitrios
    Duehren-von Minden, Marcus
    Navarrete, Marcelo
    Zirlik, Katja
    Heining-Mikesch, Kristina
    Veelken, Hendrik
    [J]. BLOOD, 2010, 116 (10) : 1734 - 1736
  • [16] MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
    Tamura, Koichiro
    Peterson, Daniel
    Peterson, Nicholas
    Stecher, Glen
    Nei, Masatoshi
    Kumar, Sudhir
    [J]. MOLECULAR BIOLOGY AND EVOLUTION, 2011, 28 (10) : 2731 - 2739
  • [17] Protection against H1N1 influenza challenge by a DNA vaccine expressing H3/H1 subtype hemagglutinin combined with MHC class II-restricted epitopes
    Tan, Lei
    Lu, Huijun
    Zhang, Dan
    Tian, Mingyao
    Hu, Bo
    Wang, Zhuoyue
    Jin, Ningyi
    [J]. VIROLOGY JOURNAL, 2010, 7
  • [18] The Immune Epitope Database 2.0
    Vita, Randi
    Zarebski, Laura
    Greenbaum, Jason A.
    Emami, Hussein
    Hoof, Ilka
    Salimi, Nima
    Damle, Rohini
    Sette, Alessandro
    Peters, Bjoern
    [J]. NUCLEIC ACIDS RESEARCH, 2010, 38 : D854 - D862
  • [19] UCSF Chimera, MODELLER, and IMP: An integrated modeling system
    Yang, Zheng
    Lasker, Keren
    Schneidman-Duhovny, Dina
    Webb, Ben
    Huang, Conrad C.
    Pettersen, Eric F.
    Goddard, Thomas D.
    Meng, Elaine C.
    Sali, Andrej
    Ferrin, Thomas E.
    [J]. JOURNAL OF STRUCTURAL BIOLOGY, 2012, 179 (03) : 269 - 278
  • [20] Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans
    Zhou, Xin
    McElhaney, Janet E.
    [J]. VACCINE, 2011, 29 (11) : 2169 - 2177
12