The role of complement in nonalcoholic fatty liver disease

被引：26

作者：

Guo, Zhenya ^{[1
,2
,3
]}

Fan, Xiude ^{[4
]}

Yao, Jianni ^{[2
,3
]}

Tomlinson, Stephen ^{[5
]}

Yuan, Guandou ^{[1
,2
,3
]}

He, Songqing ^{[1
,2
,3
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Div Hepatobiliary Surg, Nanning, Peoples R China

[2] Guangxi Med Univ, Key Lab Early Prevent & Treatment Reg High Frequen, Minist Educ, Nanning, Peoples R China

[3] Guangxi Med Univ, Guangxi Key Lab Immunol & Metab Liver Dis, Nanning, Peoples R China

[4] Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan, Peoples R China

[5] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

complement system; nonalcoholic fatty liver disease; site-targeted inhibitor; inflammation; liver; ADIPOSE-TISSUE; INSULIN-RESISTANCE; TICK-OVER; T-CELLS; INFLAMMATION; ACTIVATION; C3A; STEATOHEPATITIS; RECEPTOR; PATHOGENESIS;

D O I：

10.3389/fimmu.2022.1017467

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved in lipid metabolism. In particular, activation of the alternative complement pathway and the production of complement activation products such as C3a, C3adesArg (acylation stimulating protein or ASP) and C5a, are strongly associated with insulin resistance, lipid metabolism disorder, and hepatic inflammation. In this review, we briefly summarize research on the role of the complement system in NAFLD, aiming to provide a basis for the development of novel therapeutic strategies for NAFLD.

引用

页数：9

共 84 条

[1] Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity [J].

Antonucci, Laura ;

Porcu, Cristiana ;

Timperi, Eleonora ;

Santini, Silvano Junior ;

Iannucci, Gino ;

Balsano, Clara .

JOURNAL OF IMMUNOLOGY RESEARCH, 2020, 2020

[2] C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation [J].

Asgari, Elham ;

Le Friec, Gaelle ;

Yamamoto, Hidekazu ;

Perucha, Esperanza ;

Sacks, Steven S. ;

Koehl, Joerg ;

Cook, H. Terence ;

Kemper, Claudia .

BLOOD, 2013, 122 (20) :3473-3481

[3] Complement activation, regulation, and molecular basis for complement-related diseases [J].

Bajic, Goran ;

Degn, Soren E. ;

Thiel, Steffen ;

Andersen, Gregers R. .

EMBO JOURNAL, 2015, 34 (22) :2735-2757

[4] The role of complement factor C3 in lipid metabolism [J].

Barbu, Andreea ;

Hamad, Osama A. ;

Lind, Lars ;

Ekdahl, Kristina N. ;

Nilsson, Bo .

MOLECULAR IMMUNOLOGY, 2015, 67 (01) :101-107

[5] The complement component C5 promotes liver steatosis and inflammation in murine non-alcoholic liver disease model [J].

Bavia, Lorena ;

Cogliati, Bruno ;

Dettoni, Juliano Bertollo ;

Ferreira Alves, Venancio Avancini ;

Isaac, Lourdes .

IMMUNOLOGY LETTERS, 2016, 177 :53-61

[6] Molecular pathways of nonalcoholic fatty liver disease development and progression [J].

Bessone, Fernando ;

Valeria Razori, Maria ;

Roma, Marcelo G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (01) :99-128

[7] The tick-over theory revisited:: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb) [J].

Bexborn, Fredrik ;

Andersson, Per Ola ;

Chen, Hui ;

Nilsson, Bo ;

Ekdahl, Kristina N. .

MOLECULAR IMMUNOLOGY, 2008, 45 (08) :2370-2379

[8] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[9] The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD) [J].

Buzzetti, Elena ;

Pinzani, Massimo ;

Tsochatzis, Emmanuel A. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (08) :1038-1048

[10] The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis [J].

Cai, Jingjing ;

Zhang, Xiao-Jing ;

Li, Hongliang .

HEPATOLOGY, 2019, 70 (03) :1026-1037

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