Rhodium-catalyzed regioselective direct C-H arylation of indoles with aryl boronic acids

被引：35

作者：

Wang, Liang ^{[1
,2
]}

Qu, Xing ^{[1
]}

Li, Zhan ^{[1
]}

Peng, Wang-Ming ^{[1
]}

机构：

[1] Jianghan Univ, Minist Educ, Key Lab Optoelect Chem Mat & Devices, Wuhan 430056, Hubei, Peoples R China

[2] Jianghan Univ, Sch Chem & Enviromental Engn, Wuhan 430056, Hubei, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 24期

基金：

美国国家科学基金会;

关键词：

C-H arylation; Indoles; Aryl botanic acids; Rhodium-catalysis; DIRECT C-2 ARYLATION; ONE-POT SYNTHESIS; ROOM-TEMPERATURE; BOND FORMATION; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; ARENES; MILD; CLEAVAGE;

D O I：

10.1016/j.tetlet.2015.04.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient Rh(III)-catalyzed direct C-H arylation of indoles with aryl boronic acids under mild conditions has been developed. The methodology features wide substrate scope and excellent functional group compatibility (34 examples, up to 99% yield). The arylated products can also be conveniently transformed into biologically active polycyclic indole derivatives. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3754 / 3757

页数：4

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