A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

被引：106
作者：
Guo, Ting [1 ]
Cui, Lei [1 ]
Shen, Jiaoning [1 ]
Wang, Rui [1 ]
Zhu, Weiping [1 ]
Xu, Yufang [1 ]
Qian, Xuhong [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 18期
基金：
国家高技术研究发展计划(863计划);
关键词：
HYPOCHLOROUS-ACID; REACTIVE OXYGEN; NITRIC-OXIDE; MYELOPEROXIDASE; PEROXYNITRITE; SUPEROXIDE; BIOLOGY; STRESS; DESIGN;
D O I：
10.1039/c3cc38471c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO-). Upon addition of ClO-, significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO- led to only a single-channel fluorescence enhancement. This feature makes it a clear advantage in distinguishing ClO-, RNS from other ROS.
引用
收藏
页码：1862 / 1864
页数：3
相关论文
共 44 条
[1]   ANODIC OXIDATIONS OF AROMATIC AMINES .3. SUBSTITUTED ANILINES IN AQUEOUS MEDIA [J].
BACON, J ;
ADAMS, RN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (24) :6596-&
[2]   Neurodegenerative diseases and oxidative stress [J].
Barnham, KJ ;
Masters, CL ;
Bush, AI .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) :205-214
[3]   APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].
BECKMAN, JS ;
BECKMAN, TW ;
CHEN, J ;
MARSHALL, PA ;
FREEMAN, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624
[4]   Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation [J].
Bove, Peter F. ;
van der Vliet, Albert .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (04) :515-527
[5]   A NOVEL CONNECTOR LINKAGE APPLICABLE IN PRODRUG DESIGN [J].
CARL, PL ;
CHAKRAVARTY, PK ;
KATZENELLENBOGEN, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) :479-480
[6]   FRET spectral unmixing: a ratiometric fluorescent nanoprobe for hypochlorite [J].
Chen, Gengwen ;
Song, Fengling ;
Wang, Jingyun ;
Yang, Zhigang ;
Sun, Shiguo ;
Fan, Jiangli ;
Qiang, Xinxin ;
Wang, Xu ;
Dou, Bairui ;
Peng, Xiaojun .
CHEMICAL COMMUNICATIONS, 2012, 48 (24) :2949-2951
[7]   Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species [J].
Chen, Xiaoqiang ;
Tian, Xizhe ;
Shin, Injae ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2011, 40 (09) :4783-4804
[8]   A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production [J].
Chen, Xiaoqiang ;
Lee, Kyung-Ah ;
Ha, Eun-Mi ;
Lee, Kyung Mi ;
Seo, You Yeong ;
Choi, Han Kyoung ;
Kim, Ha Na ;
Kim, Min Jung ;
Cho, Chun-Seok ;
Lee, Soo Young ;
Lee, Won-Jae ;
Yoon, Juyoung .
CHEMICAL COMMUNICATIONS, 2011, 47 (15) :4373-4375
[9]   A highly selective and sensitive fluorescence probe for the hypochlorite anion [J].
Chen, Xinqi ;
Wang, Xiaochun ;
Wang, Shajuan ;
Shi, Wen ;
Wang, Ke ;
Ma, Huimin .
CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (15) :4719-4724
[10]   A "turn-on" fluorescent probe for hypochlorous acid: convenient synthesis, good sensing performance, and a new design strategy by the removal of C=N isomerization [J].
Cheng, Xiaohong ;
Jia, Huizhen ;
Long, Teng ;
Feng, Jun ;
Qin, Jingui ;
Li, Zhen .
CHEMICAL COMMUNICATIONS, 2011, 47 (43) :11978-11980
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