European Organization for Caries Research Workshop: Methodology for Determination of Potentially Available Fluoride in Toothpastes

被引：26

作者：

Martinez-Mier, E. Angeles ^{[1
]}

Tenuta, Livia Maria Andalo ^{[2
]}

Carey, Clifton M. ^{[3
]}

Cury, Jaime A. ^{[4
]}

van Loveren, Cor ^{[5
,6
]}

Ekstrand, Kim Rud ^{[7
]}

Ganss, Carolina ^{[8
]}

Schulte, Andreas ^{[9
]}

Baig, Arif ^{[10
]}

Benzian, Habib ^{[11
]}

Bottenberg, Peter ^{[12
]}

Buijs, Mark J. ^{[5
,6
]}

Ceresa, Alan ^{[13
]}

Carvalho, Joana Christina ^{[14
]}

Ellwood, Roger ^{[15
]}

Gonzalez-Cabezas, Carlos ^{[2
]}

Holmgren, Christopher ^{[16
]}

Knapp, Michael ^{[12
]}

Lippert, Frank ^{[1
]}

Joiner, Andrew ^{[17
]}

Manton, David J. ^{[18
]}

Martignon, Stefania ^{[19
,20
]}

Mason, Stephen ^{[19
,21
]}

Jablonski-Momeni, Anahita ^{[22
]}

Plett, Walter ^{[23
]}

Rahiotis, Chris ^{[24
]}

Sampaio, Fabio ^{[25
]}

Zero, Domenick T. ^{[1
]}

机构：

[1] Indiana Univ, Sch Dent, Dept Cariol Operat Dent & Dent Publ Hlth, Indianapolis, IN 46202 USA

[2] Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA

[3] Univ Colorado, Sch Dent Med, Dept Craniofacial Biol, Anschutz Med Campus, Aurora, CO USA

[4] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, Brazil

[5] Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Prevent Dent, Amsterdam, Netherlands

[6] Vrije Univ, Amsterdam, Netherlands

[7] Univ Copenhagen, Dept Odontol, Copenhagen, Denmark

[8] Justus Liebig Univ, Dept Conservat & Prevent Dent, Giessen, Germany

[9] Univ Witten Herdecke, Dept Special Care Dent, Witten, Germany

[10] Procter & Gamble Co, Hlth Care Res Ctr, Mason, OH USA

[11] NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USA

[12] Vrije Univ Brussel, Oral Hlth Res Grp, Brussels, Belgium

[13] Colgate Palmol Europe, Therwil, Switzerland

[14] Catholic Univ Louvain, Fac Med & Dent, Brussels, Belgium

[15] Univ Manchester, Colgate Palmol Dent Hlth Unit, Manchester, Lancs, England

[16] Aide Odontol Int, Montrouge, France

[17] Unilever Oral Care, Wirral, Merseyside, England

[18] Univ Melbourne, Melbourne Dent Sch, Carlton, Vic, Australia

[19] Univ El Bosque, UNICA Caries Res Unit, Res Vice Rectory, Bogota, Colombia

[20] Kings Coll London, Dent Innovat & Translat Ctr, Inst Dent, London, England

[21] GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey, England

[22] Philipps Univ, Dept Pediat & Community Dent, Marburg, Germany

[23] Heidelberg Univ, Dept Conservat Dent, Heidelberg, Germany

[24] Natl & Kapodistrian Univ Athens, Dept Operat Dent, Fac Dent, Athens, Greece

[25] Univ Fed Paraiba, Ctr Ciencias Saude, Joao Pessoa, Paraiba, Brazil

来源：

CARIES RESEARCH | 2019年 / 53卷 / 02期

关键词：

Research Workshop; Fluoride; Fluoride Analysis; Toothpastes; Available Fluoride; DENTIFRICES; SALIVA;

D O I：

10.1159/000490196

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Toothpastes are the most universally accepted form of fluoride delivery for caries prevention. To provide anti-caries benefits, they must be able to release fluoride during the time of tooth brushing or post brushing into the oral cavity. However, there is no standard accepted procedure to measure how much fluoride in a toothpaste may be (bio)available for release. The European Organization for Caries Research proposed and supported a workshop with experts in fluoride analysis in toothpastes and representatives from industry. The objective of the workshop was to discuss issues surrounding fluoride analysis in toothpaste and reach consensus on terminology and best practices, wherever the available evidence allowed it. Participants received a background paper and heard presentations followed by structured discussion to define the problem. The group also reviewed evidence on the validity, reliability and feasibility of each technique (namely chromatography and fluoride electroanalysis) and discussed their strengths and limitations. Participants were able to reach a consensus on terminology and were also able to identify and summarize the advantages and disadvantages of each technique. However, they agreed that most currently available methods were developed for regulatory agencies several decades ago, utilizing the best available data from clinical trials then, but require to be updated. They also agreed that although significant advances to our understanding of the mechanism of action of fluoride in toothpaste have been achieved over the past 4 decades, this clearly is an extraordinarily complex subject and more work remains to be done. (c) 2018 S. Karger AG, Basel

引用

页码：119 / 136

页数：18

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