Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats

被引：53

作者：

Qian, Lihua ^{[1
]}

Shen, Minzhe ^{[1
]}

Tang, Hao ^{[1
]}

Tang, Yuping ^{[1
]}

Zhang, Li ^{[1
]}

Fu, Yifan ^{[1
]}

Shi, Qianping ^{[1
]}

Li, Nian-Guang ^{[1
,2
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Med Chem, Nanjing 210046, Jiangsu, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 09期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

scutellarein; scutellarin; synthesis; MCAO; focal cerebral ischemia/reperfusion; ARTERY OCCLUSION; INJURY; ISCHEMIA; METABOLISM; THERAPY;

D O I：

10.3390/molecules170910667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. Neurological deficit score and cerebral infarction volume with the administration of scutellarein were then used to compare its neuroprotective effects on focal cerebral ischemia/reperfusion in rats induced by middle cerebral artery occlusion (MCAO) with those of scutellarin. The results showed that scutellarein had better protective effect on focal cerebral ischemia/reperfusion than scutellarin, which laid the foundation for further research and development of scutellarein as a promising candidate for ischemic cerebro-vascular disease.

引用

页码：10667 / 10674

页数：8

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