The emergence of mecC methicillin-resistant Staphylococcus aureus

被引：320

作者：

Paterson, Gavin K. ^{[1
]}

Harrison, Ewan M. ^{[1
]}

Holmes, Mark A. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 01期

基金：

英国医学研究理事会;

关键词：

methicillin-resistant Staphylococcus aureus (MESA); mecC; zoonosis; antibiotic resistance; molecular epidemiology; genome sequencing; GENETIC HOMOLOG; MRSA; DIVERSITY; VARIANT; TRANSMISSION; POPULATIONS; PREVALENCE; ANIMALS; DENMARK; ASSAY;

D O I：

10.1016/j.tim.2013.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The report of methicillin-resistant Staphylococcus aureus (MRSA) encoding a divergent mecA gene in 2011 was highly significant. This homologue, designated mecC, poses diagnostic problems with the potential to be misdiagnosed as methicillin-sensitive S. aureus, with important potential consequences for individual patients and for the surveillance of MRSA. mecC MRSA have now been reported from 13 European countries and have been isolated from 14 different host species, with evidence of a recent increase in Denmark. The emergence of mecC MRSA is a topic of interest to human and veterinary microbiology, and we consider it timely to review here its discovery and subsequent investigation.

引用

页码：42 / 47

页数：6

共 49 条

[1] A novel field-based approach to validate the use of network models for disease spread between dairy herds [J].

Alvarez, L. Garcia ;

Webb, C. R. ;

Holmes, M. A. .

EPIDEMIOLOGY AND INFECTION, 2011, 139 (12) :1863-1874

[2] Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene [J].

Ba, Xiaoliang ;

Harrison, Ewan M. ;

Edwards, Giles F. ;

Holden, Matthew T. G. ;

Larsen, Anders Rhod ;

Petersen, Andreas ;

Skov, Robert L. ;

Peacock, Sharon J. ;

Parkhill, Julian ;

Paterson, Gavin K. ;

Holmes, Mark A. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (03) :594-597

[3] Severe human bone infection due to methicillin-resistant Staphylococcus aureus carrying the novel mecC variant [J].

Barraud, Olivier ;

Laurent, Frederic ;

Francois, Bruno ;

Bes, Michele ;

Vignon, Philippe ;

Ploy, Marie-Cecile .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (12) :2949-2950

[4] Very low prevalence of meticillin-resistant Staphylococcus aureus carrying the mecC gene in western Switzerland [J].

Basset, P. ;

Prod'hom, G. ;

Senn, L. ;

Greub, G. ;

Blanc, D. S. .

JOURNAL OF HOSPITAL INFECTION, 2013, 83 (03) :257-259

[5] Evaluation of a Modular Multiplex-PCR Methicillin-Resistant Staphylococcus aureus Detection Assay Adapted for mecC Detection [J].

Becker, Karsten ;

Larsen, Anders R. ;

Skov, Robert L. ;

Paterson, Gavin K. ;

Holmes, Mark A. ;

Sabat, Artur J. ;

Friedrich, Alexander W. ;

Koeck, Robin ;

Peters, Georg ;

Kriegeskorte, Andre .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (06) :1917-1919

[6] Comparison of Xpert MRSA/SA Nasal and MRSA/SA ELITe MGB Assays for Detection of the mecA Gene with Susceptibility Testing Methods for Determination of Methicillin Resistance in Staphylococcus aureus Isolates [J].

Belmekki, Mohamed ;

Mammeri, Hedi ;

Hamdad, Farida ;

Rousseau, Florence ;

Canarelli, Brigitte ;

Biendo, Maurice .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (10) :3183-3191

[7] Use of Vitek 2 Antimicrobial Susceptibility Profile To Identify mecC in Methicillin-Resistant Staphylococcus aureus [J].

Cartwright, Edward J. P. ;

Paterson, Gavin K. ;

Raven, Kathy E. ;

Harrison, Ewan M. ;

Gouliouris, Theodore ;

Kearns, Angela ;

Pichon, Bruno ;

Edwards, Giles ;

Skov, Robert L. ;

Larsen, Anders R. ;

Holmes, Mark A. ;

Parkhill, Julian ;

Peacock, Sharon J. ;

Toeroek, M. Estee .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (08) :2732-2734

[8] Clonal diversity of Staphylococcus aureus originating from the small ruminants goats and sheep [J].

Concepcion Porrero, M. ;

Hasman, Henrik ;

Vela, Ana I. ;

Fernandez-Garayzabal, Jose F. ;

Dominguez, Lucas ;

Aarestrup, Frank M. .

VETERINARY MICROBIOLOGY, 2012, 156 (1-2) :157-161

[9] Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri [J].

Couto, I ;

deLencastre, H ;

Severina, E ;

Kloos, W ;

Webster, JA ;

Hubner, RJ ;

Sanches, IS ;

Tomasz, A .

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1996, 2 (04) :377-391

[10] Rare Occurrence of Methicillin-Resistant Staphylococcus aureus CC130 with a Novel mecA Homologue in Humans in Germany [J].

Cuny, Christiane ;

Layer, Franziska ;

Strommenger, Birgit ;

Witte, Wolfgang .

PLOS ONE, 2011, 6 (09)

← 1 2 3 4 5 →