Formamidobisabolene-based derivatives from a sponge Axinyssa sp.

被引：14

作者：

Cheng, Wei ^{[1
]}

Liu, Dong ^{[1
]}

Zhang, Fengying ^{[1
]}

Zhang, Qingying ^{[1
]}

Pedpradab, Patchara ^{[2
]}

Proksch, Peter ^{[3
]}

Liang, Hong ^{[1
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Rajamangala Univ Technol Srivijaya, Dept Marine Sci, Trang 92150, Thailand

[3] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

TETRAHEDRON | 2014年 / 70卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Sponge; Axinyssa sp; Formamidobisabolenes; Structural elucidation; Antimicrobial activities; BISABOLENE-TYPE SESQUITERPENES; SOUTH CHINA SEA; ABSOLUTE-CONFIGURATION; MARINE SPONGE; METABOLITES; NUDIBRANCH; ALCOHOLS; BIOSYNTHESIS; MO-2(OAC)(4); ASSIGNMENT;

D O I：

10.1016/j.tet.2014.04.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical examination of a Chinese sponge Axinyssa sp. resulted in the isolation of 12 new formamidobisabolene-based analogues named axinyssines A-L (1-12), along with a new natural product (13) and three known formamidobisabolenes (14-16). Their structures were determined on the basis of extensive NMR and mass spectroscopic analyses in association with ICD data, Mosher reaction and chemical conversion for the assignment of absolute configurations. All compounds were evaluated for antitumor and antimicrobial activities. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3576 / 3583

页数：8

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