Acellular pertussis vaccine in children with perinatal human immunodeficiency virus-type 1 infection

被引：18

作者：

deMartino, M

Podda, A

Galli, L

Sinangil, F

Mannelli, F

Rossi, ME

Vierucci, A

机构：

[1] CHIRON VACCINES,I-53100 SIENA,ITALY

[2] UNIV FLORENCE,DEPT PEDIAT,I-50133 FLORENCE,ITALY

来源：

VACCINE | 1997年 / 15卷 / 11期

关键词：

acellular pertussis vaccine; HIV-1 perinatal infection; immunization; pertussis;

D O I：

10.1016/S0264-410X(97)00024-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin, filamentous haemoagglutinin and pertactin was studied in 12 children [median age, 45 (6-107) months] with perinatal human immunodeficiency virus-type I (HIV-I) infection, Antibody response to all antigens was observed in six cases and another children 3 reacted to two or one antigen(s), but titres were lower than those from healthy controls, Antibody title fold-rise correlated with preimmunization CD4-positive cell counts, Significant titles were still detectable 4 months after the third nose, The acellular vaccine is immunogenic in a portion of children with perinatal HIV-I infection but early vaccination might be mole effective, taking advantage of still adequate CD4-positive cell numbers. (C) 1997 Elsevier Science Ltd.

引用

页码：1235 / 1238

页数：4

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