A Cooperative Copper- and Palladium-Catalyzed Three-Component Coupling of Benzynes, Allylic Epoxides, and Terminal Alkynes

被引：77

作者：

Jeganmohan, Masilanzani ^{[1
]}

Bhuvaneswari, Sivakolundu ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 02期

关键词：

arynes; copper; cross-coupling; cyclization; palladium; HIGHLY EFFICIENT ROUTE; ARYL HALIDES; ARYNES; ACTIVATION; CYCLOISOMERIZATION; CARBOCYCLIZATION; CARBOPALLADATION; ALKENES;

D O I：

10.1002/anie.200804873

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A little cooperation: A cooperative copper- and palladium-catalyzed highly regio- and chemoselective three-component coupling of benzynes, allylic epoxides, and terminal alkynes provides an efficient atom-economical route to ortho-disubstituted arenes. The resulting product undergoes a gold-catalyzed cyclization reaction (see scheme; dba=dibenzylideneacetone, dppp=1,3-bis(diphenylphosphanyl)propane). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：391 / 394

页数：4

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