Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

被引：0

作者：

Fujii, Hikaru ^{[1
,2
]}

Harada, Shizuko ^{[1
]}

Yoshikawa, Tomoki ^{[1
]}

Yamada, Souichi ^{[1
]}

Omura, Natsumi ^{[1
,3
]}

Shibamura, Miho ^{[1
,4
]}

Inagaki, Takuya ^{[1
,3
]}

Kato, Hirofumi ^{[1
]}

Fukushi, Shuetsu ^{[1
]}

Saijo, Masayuki ^{[1
,3
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

[2] Okayama Univ Sci, Fac Vet Med, Imabari, Ehime, Japan

[3] Waseda Univ, Dept Life Sci & Med Biosci, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Pediat, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 05期

关键词：

DNA polymerase; acyclovir; acyclovir resistant; herpes simplex virus 1; thymidine kinase; varicella-zoster virus; DNA-POLYMERASE GENES; IN-VITRO; GENOTYPIC CHARACTERIZATION; SENSITIVITY; INFECTION; THERAPY; PATIENT; TYPE-1; CONSTRUCTION; PROPHYLAXIS;

D O I：

10.1128/AAC.00017-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene. In contrast, recombinant HSV-1 expressing HSV-1 TK ectopically harbored mutations in the HSV-1 TK gene. These results suggest that the relatively low frequency of ACV-resistant VZV is a consequence of the characteristics of the TK gene.

引用

页数：6

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