Toll signaling: RIPping off the TNF pathway

被引：20

作者：

Barton, GM ^{[1
]}

Medzhitov, R ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 05期

关键词：

D O I：

10.1038/ni0504-472

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction by certain TLR family members.

引用

页码：472 / 474

页数：4

共 13 条

[1] TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM [J].

Couillault, C ;

Pujol, N ;

Reboul, J ;

Sabatier, L ;

Guichou, JF ;

Kohara, Y ;

Ewbank, JJ .

NATURE IMMUNOLOGY, 2004, 5 (05) :488-494

[2] IKKε and TBK1 are essential components of the IRF3 signaling pathway [J].

Fitzgerald, KA ;

McWhirter, SM ;

Faia, KL ;

Rowe, DC ;

Latz, E ;

Golenbock, DT ;

Coyle, AJ ;

Liao, SM ;

Maniatis, T .

NATURE IMMUNOLOGY, 2003, 4 (05) :491-496

[3] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-κB activation and apoptosis pathways [J].

Han, KJ ;

Su, XQ ;

Xu, LG ;

Bin, LH ;

Zhang, J ;

Shu, HB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15652-15661

[4] Identification of Lps2 as a key transducer of MyD88-independent TIR signalling [J].

Hoebe, K ;

Du, X ;

Georgel, P ;

Janssen, E ;

Tabeta, K ;

Kim, SO ;

Goode, J ;

Lin, P ;

Mann, N ;

Mudd, S ;

Crozat, K ;

Sovath, S ;

Han, J ;

Beutler, B .

NATURE, 2003, 424 (6950) :743-748

[5] The death domain kinase RIP mediates the TNF-induced NF-κB signal [J].

Kelliher, MA ;

Grimm, S ;

Ishida, Y ;

Kuo, F ;

Stanger, BZ ;

Leder, P .

IMMUNITY, 1998, 8 (03) :297-303

[6] IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts [J].

McWhirter, SM ;

Fitzgerald, KA ;

Rosains, J ;

Rowe, DC ;

Golenbock, DT ;

Maniatis, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :233-238

[7] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation [J].

Meylan, E ;

Burns, K ;

Hofmann, K ;

Blancheteau, V ;

Martinon, F ;

Kelliher, M ;

Tschopp, J .

NATURE IMMUNOLOGY, 2004, 5 (05) :503-507

[8] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes [J].

Micheau, O ;

Tschopp, J .

CELL, 2003, 114 (02) :181-190

[9] Kinase RIP3 is dispensable for normal NF-KBs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and toll-like receptors 2 and 4 [J].

Newton, K ;

Sun, XQ ;

Dixit, VM .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (04) :1464-1469

[10] TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction [J].

Oshiumi, H ;

Matsumoto, M ;

Funami, K ;

Akazawa, T ;

Seya, T .

NATURE IMMUNOLOGY, 2003, 4 (02) :161-167

← 1 2 →