A Library of Multifunctional Polyesters with "Peptide-Like" Pendant Functional Groups

被引：53

作者：

Gokhale, Sachin ^{[1
]}

Xu, Ying ^{[1
]}

Joy, Abraham ^{[1
]}

机构：

[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA

来源：

BIOMACROMOLECULES | 2013年 / 14卷 / 08期

关键词：

D O I：

10.1021/bm400697u

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and characterization of a library of modular multifunctional polyesters with pendant functional groups are described. The polyesters were synthesized at room temperature by carbodiimide-mediated polymerization of pendant functionalized diols and succinic acid. The pendant groups are designed to mimic the side chains of peptides, and it is shown that the physical properties of the polyesters can be modulated over a wide range by the choice of pendant groups. We also show that the pendant groups can be orthogonally functionalized with ligands such as fluorophores, poly(ethylene glycol) (PEG) or Arg-Gly-Asp (RGD).

引用

页码：2489 / 2493

页数：5

共 58 条

[1] A Versatile Approach for the Syntheses of Poly(ester amide)s with Pendant Functional Groups [J].

Atkins, Katelyn M. ;

Lopez, David ;

Knight, Darryl K. ;

Mequanint, Kibret ;

Gillies, Elizabeth R. .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2009, 47 (15) :3757-3772

[2] Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells [J].

Benoit, Danielle S. W. ;

Schwartz, Michael P. ;

Durney, Andrew R. ;

Anseth, Kristi S. .

NATURE MATERIALS, 2008, 7 (10) :816-823

[3]

Brocchini S, 1998, J BIOMED MATER RES, V42, P66, DOI 10.1002/(SICI)1097-4636(199810)42:1<66::AID-JBM9>3.3.CO

[4]

2-B

[5] Well-Defined Poly(lactic acid)s Containing Poly(ethylene glycol) Side Chains [J].

Castillo, Jose A. ;

Borchmann, Dorothee E. ;

Cheng, Amy Y. ;

Wang, Yufeng ;

Hu, Chunhua ;

Garcia, Andres J. ;

Weck, Marcus .

MACROMOLECULES, 2012, 45 (01) :62-69

[6] Efficient synthesis of multifunctional polymers via thiol-epoxy "click" chemistry [J].

De, Swati ;

Khan, Anzar .

CHEMICAL COMMUNICATIONS, 2012, 48 (25) :3130-3132

[7] Synthesis and Characterization of Biodegradable Poly(ester amide)s with Pendant Amine Functional Groups and In Vitro Cellular Response [J].

Deng, Mingxiao ;

Wu, Jun ;

Reinhart-King, Cynthia A. ;

Chu, Chih-Chang .

BIOMACROMOLECULES, 2009, 10 (11) :3037-3047

[8] Synthesis and characterization of polyesters based on tartaric acid derivatives [J].

Dhamaniya, Sunil ;

Jacob, Josemon .

POLYMER, 2010, 51 (23) :5392-5399

[9] Ring-Opening Copolymerization of Maleic Anhydride with Epoxides: A Chain-Growth Approach to Unsaturated Polyesters [J].

DiCiccio, Angela M. ;

Coates, Geoffrey W. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (28) :10724-10727

[10] Synthesis and characterization of random copolyesters of ε-caprolactone and 2-oxepane-1,5-dione [J].

Dwan'Isa, JPL ;

Lecomte, P ;

Dubois, P ;

Jérôme, R .

MACROMOLECULES, 2003, 36 (08) :2609-2615

← 1 2 3 4 5 6 →