The difficult search for a 'partner' of statins in lipid-targeted prevention of vascular events: the re-emergence and fall of niacin

被引：16
作者：
Landmesser, Ulf [1 ]
机构：
[1] Univ Zurich Hosp, CH-8091 Zurich, Switzerland
来源：
EUROPEAN HEART JOURNAL | 2013年 / 34卷 / 17期
关键词：
NICOTINIC-ACID; EXTENDED-RELEASE; CHOLESTEROL; HDL; RATIONALE;
D O I：
10.1093/eurheartj/eht064
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：1254 / 1257
页数：4
相关论文
共 20 条
[1]   INFLUENCE OF NICOTINIC ACID ON SERUM CHOLESTEROL IN MAN [J].
ALTSCHUL, R ;
HOFFER, A ;
STEPHEN, JD .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1955, 54 (02) :558-559
[2]  
[Anonymous], 1975, JAMA-J AM MED ASSOC, V231, P360
[3]   Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [J].
Baigent, C. ;
Blackwell, L. ;
Emberson, J. ;
Holland, L. E. ;
Reith, C. ;
Bhala, N. ;
Peto, R. ;
Barnes, E. H. ;
Keech, A. ;
Simes, J. ;
Collins, R. .
LANCET, 2010, 376 (9753) :1670-1681
[4]   GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing [J].
Benyó, Z ;
Gille, A ;
Kero, J ;
Csiky, M ;
Suchánková, MC ;
Nüsing, RM ;
Moers, A ;
Pfeffer, K ;
Offermanns, S .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3634-3640
[5]   Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease [J].
Besler, Christian ;
Heinrich, Kathrin ;
Rohrer, Lucia ;
Doerries, Carola ;
Riwanto, Meliana ;
Shih, Diana M. ;
Chroni, Angeliki ;
Yonekawa, Keiko ;
Stein, Sokrates ;
Schaefer, Nicola ;
Mueller, Maja ;
Akhmedov, Alexander ;
Daniil, Georgios ;
Manes, Costantina ;
Templin, Christian ;
Wyss, Christophe ;
Maier, Willibald ;
Tanner, Felix C. ;
Matter, Christian M. ;
Corti, Roberto ;
Furlong, Clement ;
Lusis, Aldons J. ;
von Eckardstein, Arnold ;
Fogelman, Alan M. ;
Luescher, Thomas F. ;
Landmesser, Ulf .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (07) :2693-2708
[6]   Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy [J].
Boden, William E. ;
Probstfield, Jeffrey L. ;
Anderson, Todd ;
Chaitman, Bernard R. ;
Desvignes-Nickens, Patrice ;
Koprowicz, Kent ;
McBride, Ruth ;
Teo, Koon ;
Weintraub, William .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) :2255-2267
[7]   Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice [J].
Hanson, Julien ;
Gille, Andreas ;
Zwykiel, Sabrina ;
Lukasova, Martina ;
Clausen, Bjorn E. ;
Ahmed, Kashan ;
Tunaru, Sorin ;
Wirth, Angela ;
Offermanns, Stefan .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (08) :2910-2919
[8]   HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment [J].
Haynes, Richard ;
Jiang, Lixin ;
Hopewell, Jemma C. ;
Li, Jing ;
Chen, Fang ;
Parish, Sarah ;
Landray, Martin J. ;
Collins, Rory ;
Armitage, Jane .
EUROPEAN HEART JOURNAL, 2013, 34 (17) :1279-1291
[9]   Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells [J].
Lukasova, Martina ;
Malaval, Camille ;
Gille, Andreas ;
Kero, Jukka ;
Offermanns, Stefan .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (03) :1163-1173
[10]   Flushing Profile of Extended-Release Niacin/Laropiprant Versus Gradually Titrated Niacin Extended-Release in Patients With Dyslipidemia With and Without Ischemic Cardiovascular Disease [J].
Maccubbin, Dorbie ;
Koren, Michael J. ;
Davidson, Michael ;
Gavish, Dov ;
Pasternak, Richard C. ;
Macdonell, Geraldine ;
Mallick, Madhuja ;
Sisk, Christine McCrary ;
Paolini, John F. ;
Mitchel, Yale .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (01) :74-81
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