Effects of CCK-8 and Cystathionine γ-Lyase/Hydrogen Sulfide System on Acute Lung Injury in Rats

被引：15

作者：

Tian, Fengjun ^{[1
]}

Ling, Yiling ^{[2
]}

Chen, Yuqin ^{[1
]}

Wang, Zhiyong ^{[3
]}

机构：

[1] Hebei Med Univ, Hosp 3, Dept Resp 2, Shijiazhuang, Hebei, Peoples R China

[2] Hebei Med Univ, Dept Pathophysiol, Shijiazhuang, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 3, Dept Crit Care Med, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China

来源：

INFLAMMATION | 2017年 / 40卷 / 01期

关键词：

acute lung injury (ALI); cholecystokinin-octapeptide (CCK-8); lipopolysaccharide (LPS); hydrogen sulfide (H2S); cystathionine gamma-lyase (CSE); HYDROGEN-SULFIDE; PATHWAY; CELLS;

D O I：

10.1007/s10753-016-0466-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute lung injury (ALI) is mainly characterized by diffusive injuries to lung epithelium and increased permeability of alveolar-capillary membranes caused by various factors, which leads to pulmonary edema and pulmonary closure. Lipopolysaccharide (LPS), which is the main component of the cell wall of gram-negative bacteria, is one of the most important factors causing pulmonary infection and ALI. More and more reports have indicated that hydrogen sulfide (H2S) is closely correlated with ALI and has anti-inflammation function, while the specific mechanism needs further investigation. Cholecystokinin-octapeptide (CCK-8), which is an important endogenous functional fragment belonging to CCK family, participates in anti-inflammatory and anti-endotoxic shock (ES). Whether CCK-8 plays important roles in curing ALI also needs further investigation. Herein, we concluded that CCK-8 alleviated the ALI induced by LPS via regulating the catalytic activity of cystathionine gamma-lyase (CSE) and the formation of H2S. This work provides new medicine-designed target for clinical doctor to prevent and cure ALI.

引用

页码：174 / 183

页数：10