Efficacy and toxicity of plerixafor for peripheral blood stem cell mobilization in children with high-risk neuroblastoma

被引：8

作者：

Son, Meong Hi ^{[1
]}

Kang, Eun Suk ^{[2
]}

Kim, Dong Hwan ^{[1
]}

Lee, Soo Hyun ^{[1
]}

Yoo, Keon Hee ^{[1
]}

Sung, Ki Woong ^{[1
]}

Koo, Hong Hoe ^{[1
]}

Kim, Dae Won ^{[2
]}

Kim, Ju Youn ^{[1
]}

Cho, Eun Joo ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Pediat, Samsung Med Ctr, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Sch Med, Dept Lab Med, Samsung Med Ctr, Seoul 135710, South Korea

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 08期

关键词：

children; neuroblastoma; plerixafor; stem cell mobilization; COLONY-STIMULATING FACTOR; AND/OR CYTOKINE TREATMENT; NON-HODGKINS-LYMPHOMA; PLUS G-CSF; PEDIATRIC-PATIENTS; MULTIPLE-MYELOMA; MIGRATION; AMD3100; CD34+CELLS;

D O I：

10.1002/pbc.24506

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six patients with high-risk neuroblastoma underwent the second stem cell collection round with G-CSF (5g/kg/day)+plerixafor (0.24mg/kg/day) because the amount of CD34+ cells collected during the first collection round with G-CSF alone was insufficient. The number of CD34+ cells collected in the second collection round was higher in four patients and lower in two patients than in the first collection round. Four of the six patients experienced nightmares, nyctophobia, and visual hallucinations with G-CSF+plerixafor, which were not observed with G-CSF alone. Our findings suggest that plerixafor needs to be used with caution in children. Pediatr Blood Cancer 2013;60E57-E59. (c) 2013 Wiley Periodicals, Inc.

引用

页码：E57 / E59

页数：3

共 19 条

[11] Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: Results of the Chicago Pilot II study [J].

Kletzel, M ;

Katzenstein, HM ;

Haut, PR ;

Yu, AL ;

Morgan, E ;

Reynolds, M ;

Geissler, G ;

Marymount, MH ;

Liu, DC ;

Kalopurakal, JA ;

Shore, RM ;

Bardo, DK ;

Schmoldt, J ;

Rademaker, AW ;

Cohn, SL .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (09) :2284-2292

[12] Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells [J].

Lapidot, T ;

Petit, I .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (09) :973-981

[13] Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma [J].

Modak, Shakeel ;

Cheung, Irene Y. ;

Kushner, Brian H. ;

Kramer, Kim ;

Reich, Lilian ;

Cheung, Nai-Kong V. .

PEDIATRIC BLOOD & CANCER, 2012, 58 (03) :469-471

[14] The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1 [J].

Möhle, R ;

Bautz, F ;

Rafii, S ;

Moore, MAS ;

Brugger, W ;

Kanz, L .

BLOOD, 1998, 91 (12) :4523-4530

[15] The use of plerixafor in hematopoietic progenitor cell collection in pediatric patients: a single center experience [J].

Pham, Huy P. ;

Patel, Nita ;

Semedei-Pomales, Mildred ;

Bhatia, Monica ;

Schwartz, Joseph .

CYTOTHERAPY, 2012, 14 (04) :467-472

[16] CXCR4 expression in neuroblastoma primary tumors is associated with clinical presentation of bone and bone marrow metastases [J].

Russell, HV ;

Hicks, J ;

Okcu, MF ;

Nuchtern, JG .

JOURNAL OF PEDIATRIC SURGERY, 2004, 39 (10) :1506-1511

[17] Priming of Hematopoietic Progenitor Cells by Plerixafor and Filgrastim in Children With Previous Failure of Mobilization With Chemotherapy and/or Cytokine Treatment [J].

Sevilla, Julian ;

Schiavello, Elisabetta ;

Madero, Luis ;

Pardeo, Manuela ;

Guggiari, Elena ;

Baragano, Marta ;

Luksch, Roberto ;

Massimino, Maura .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2012, 34 (02) :146-150

[18]

Stumm RK, 2003, J NEUROSCI, V23, P5123

[19] Poor Mobilization of Hematopoietic Stem Cells-Definitions, Incidence, Risk Factors, and Impact on Outcome of Autologous Transplantation [J].

Wuchter, Patrick ;

Ran, Dan ;

Bruckner, Thomas ;

Schmitt, Thomas ;

Witzens-Harig, Mathias ;

Neben, Kai ;

Goldschmidt, Hartmut ;

Ho, Anthony D. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (04) :490-499

← 1 2 →