Efficacy and toxicity of plerixafor for peripheral blood stem cell mobilization in children with high-risk neuroblastoma

被引：8

作者：

Son, Meong Hi ^{[1
]}

Kang, Eun Suk ^{[2
]}

Kim, Dong Hwan ^{[1
]}

Lee, Soo Hyun ^{[1
]}

Yoo, Keon Hee ^{[1
]}

Sung, Ki Woong ^{[1
]}

Koo, Hong Hoe ^{[1
]}

Kim, Dae Won ^{[2
]}

Kim, Ju Youn ^{[1
]}

Cho, Eun Joo ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Pediat, Samsung Med Ctr, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Sch Med, Dept Lab Med, Samsung Med Ctr, Seoul 135710, South Korea

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 08期

关键词：

children; neuroblastoma; plerixafor; stem cell mobilization; COLONY-STIMULATING FACTOR; AND/OR CYTOKINE TREATMENT; NON-HODGKINS-LYMPHOMA; PLUS G-CSF; PEDIATRIC-PATIENTS; MULTIPLE-MYELOMA; MIGRATION; AMD3100; CD34+CELLS;

D O I：

10.1002/pbc.24506

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six patients with high-risk neuroblastoma underwent the second stem cell collection round with G-CSF (5g/kg/day)+plerixafor (0.24mg/kg/day) because the amount of CD34+ cells collected during the first collection round with G-CSF alone was insufficient. The number of CD34+ cells collected in the second collection round was higher in four patients and lower in two patients than in the first collection round. Four of the six patients experienced nightmares, nyctophobia, and visual hallucinations with G-CSF+plerixafor, which were not observed with G-CSF alone. Our findings suggest that plerixafor needs to be used with caution in children. Pediatr Blood Cancer 2013;60E57-E59. (c) 2013 Wiley Periodicals, Inc.

引用

页码：E57 / E59

页数：3

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