Progress in the Transition-Metal Catalyzed Oxidation of Tertiary Amines

被引：25

作者：

Li, Yuanming ^{[1
]}

Ma, Lina ^{[1
]}

Li, Zhiping ^{[1
]}

机构：

[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 04期

基金：

中国国家自然科学基金;

关键词：

tertiary amine; oxidation; transition-metal catalysis; demethylation; amide; SP(3) C-H; DEHYDROGENATIVE-COUPLING CDC; MOLECULAR-OXYGEN; N-DEALKYLATION; HYDROGEN-PEROXIDE; BONDS ADJACENT; NITROGEN ATOM; MANNICH REACTION; EASY ACCESS; ACTIVATION;

D O I：

10.6023/cjoc201301065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidation of tertiary amines is an improtant process in nature. In chemistry, organic chemists have made great efforts to study on the simulation of enzymatic funtion of oxidation with transition metal catalyst. It provide us new and efficient protocols for the synthesis of nitrogen compounds. The catalytic reactions also enhances our understanding the mechanism of the oxidation of tertiary amins in living system. During this decade, significant progress has been made in the transition metal catalyzed oxidation of tertiary amines. This review is summarized by five types of oxidative transformation of tertiary amines: (1) synthesis of N-oxides of tertiary amines; (2) oxidative Mannich reaction of tertiary amines; (3) oxidative demethylation of tertiary amines; (4) oxidative amidation of tertiary amines; (5) oxidative transformation of the substituents of tertiary amines.

引用

页码：704 / 714

页数：11

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