A New α-Pyrone Derivative from Endophytic Fungus Pestalotiopsis microspora

被引：0

作者：

Li, Xiaocong ^{[1
]}

Guo, Zhiyong ^{[2
]}

Deng, Zhangshuang ^{[2
]}

Yang, Jin ^{[2
]}

Zou, Kun ^{[1
]}

机构：

[1] Wuhan Univ, Sch Basic Med Sci, Wuhan 430071, Peoples R China

[2] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2015年 / 9卷 / 04期

关键词：

pyrone; endophytic fungus; Pestalotiopsis microspora; gibberellin synergistic activity; NATURAL-PRODUCTS; METABOLITES; TAXOL;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new alpha-pyrone derivative 1, along with four known congeners 2, 3, 4 and 5, were isolated from the solid-substrate fermentation medium of the endophytic fungus Pestalotiopsis microspore isolated from the branch of Taxus chinensis. Their structures and relative configurations were elucidated by extensive spectroscopic analysis. The cytotoxic activities of the isolated alpha-pyrone derivatives against two tumor cell lines as well as compound l's antimicrobial activity against three bacteria and three plant-pathogenic strains were evaluated. No antimicrobial activity was observed for compound 1. The cytotoxicity against Caski and HeLa tumor cell lines was insignificant. To our surprise, the known compound 4 showed significant gibberellin synergistic activity towards Distyhum chinense seeds.

引用

页码：503 / 508

页数：6

共 22 条

[1] Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products [J].

Aly, Amal H. ;

Debbab, Abdessamad ;

Kjer, Julia ;

Proksch, Peter .

FUNGAL DIVERSITY, 2010, 41 (01) :1-16

[2] Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp. [J].

Davis, Rohan A. ;

Carroll, Anthony R. ;

Andrews, Katherine T. ;

Boyle, Glen M. ;

Tran, Truc Linh ;

Healy, Peter C. ;

Kalaitzis, John A. ;

Shivas, Roger G. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (08) :1785-1790

[3] Photipyrones A and B, new pyrone derivatives from the plant endophytic fungus Pestalotiopsis photiniae [J].

Ding, Gang ;

Qi, Yingxiang ;

Liu, Shuchun ;

Guo, Liangdong ;

Chen, Xulin .

JOURNAL OF ANTIBIOTICS, 2012, 65 (05) :271-273

[4] Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata [J].

Fu, Shao-bin ;

Yang, Jun-shan ;

Cui, Jin-long ;

Meng, Qing-feng ;

Feng, Xu ;

Sun, Di-An .

FITOTERAPIA, 2011, 82 (07) :1057-1061

[5] Anticancer compounds derived from fungal endophytes: their importance and future challenges [J].

Kharwar, Ravindra N. ;

Mishra, Ashish ;

Gond, Surendra K. ;

Stierle, Andrea ;

Stierle, Donald .

NATURAL PRODUCT REPORTS, 2011, 28 (07) :1208-1228

[6] Use of a modified microplate bioassay method to investigate antibacterial activity in the Peruvian medicinal plant Peperomia galioides [J].

Langfield, RD ;

Scarano, FJ ;

Heitzman, ME ;

Kondo, M ;

Hammond, GB ;

Neto, CC .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 94 (2-3) :279-281

[7] a-Pyrones and Pyranes from the Plant Pathogenic Fungus Pestalotiopsis scirpina [J].

Li, Jian ;

Wu, Xianfu ;

Ding, Gang ;

Feng, Yu ;

Jiang, Xuejun ;

Guo, Liangdong ;

Che, Yongsheng .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (12) :2445-2452

[8] Oleanane-Type Triterpenoids from the Endophytic Fungus Pestalotiopsis clavispora Isolated from the Chinese Mangrove Plant Bruguiera sexangula [J].

Luo, Du-Qiang ;

Deng, Hui-Ying ;

Yang, Xiao-Long ;

Shi, Bao-Zhong ;

Zhang, Jing-Ze .

HELVETICA CHIMICA ACTA, 2011, 94 (06) :1041-1047

[9]

Meyer T., 1975, LIEBIGS ANN CHEM, V12, P2261

[10] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

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