The p53 Protein Does Not Facilitate Adenovirus Type 5 Replication in Normal Human Cells

被引：5

作者：

Chahal, Jasdave S. ^{[1
]}

Flint, S. J. ^{[1
]}

机构：

[1] Princeton Univ, Lewis Thomas Lab, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 10期

基金：

美国国家卫生研究院;

关键词：

E1B 55-KILODALTON PROTEIN; E4ORF6; PROTEIN; APOPTOSIS; STABILIZATION; DEGRADATION; EXPRESSION; INDUCTION; INFECTION; REQUIRES; GENES;

D O I：

10.1128/JVI.00129-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although several adenovirus type 5 (Ad5) proteins prevent deleterious consequences of activation of p53, it has been reported that viral replication proceeds more efficiently when human tumor cells produce wild-type compared to mutant p53. We have now exploited RNA interference and lentiviral vectors to achieve essentially complete knockdown of p53 in normal human cells: no effects on the kinetics or efficiency of viral gene expression or production of infectious particles were observed.

引用

页码：6044 / 6046

页数：3

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