Nitropyridyl glycosides: new glycosyl donors for enzymatic transglycosylation

被引：25

作者：

Yasukochi, T ^{[1
]}

Inaba, C ^{[1
]}

Fukase, K ^{[1
]}

Kusumoto, S ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 36期

基金：

日本学术振兴会;

关键词：

glycosidase; transglycosylation; glycosyl donor; 3-nitro-2-pyridyl glycoside;

D O I：

10.1016/S0040-4039(99)01279-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New glycosyl donors, 3-nitro-2-pyridyl and 5-nitro-2-pyridyl glycosides, proved to be effective for transglycosylation reaction catalyzed by glycosidases, such as beta-galactosidase, B-glucosidase, and N-acetyl-beta-hexosaminidase. The high solubility in water and the high reactivity of the nitropyridyl glycosides enabled the reactions under high concentrations of the donors and consequently rapid glycosyl transfer to glycosyl accepters. The yields of the transglycosylated products with the nitropyridyl glycosides were much higher than those with conventional p-nitrophenyl glycosides. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6585 / 6589

页数：5

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