Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs

被引：31

作者：

Bartok, Osnat ^{[1
]}

Kyriacou, Charalambos P. ^{[2
]}

Levine, Joel ^{[3
]}

Sehgal, Amita ^{[4
]}

Kadener, Sebastian ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

[2] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

[3] Univ Toronto, Dept Biol, Mississauga, ON L5L 1C6, Canada

[4] Univ Penn, Howard Hughes Med Inst, Dept Neurosci, Philadelphia, PA 19104 USA

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2013年 / 280卷 / 1765期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

circadian clock; post-transcriptional regulation; environment; MESSENGER-RNA; POSTTRANSCRIPTIONAL CONTROL; TEMPERATURE COMPENSATION; TRANSLATIONAL CONTROL; BEHAVIORAL RHYTHMS; PROTEIN EXPRESSION; NATURAL VARIATION; DROSOPHILA CLOCK; PHOSPHOLIPASE-C; GENE;

D O I：

10.1098/rspb.2013.0011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian (24 h) clocks provide a source of internal timing in most living organisms. These clocks keep time by using complex transcriptional/post-translational feedback loops that are strikingly resilient to changes in environmental conditions. In the last few years, interest has increased in the role of post-transcriptional regulation of circadian clock components. Post-transcriptional control plays a prominent role in modulating rapid responses of the circadian system to environmental changes, including light, temperature and general stress and will be the focus of this review.

引用

页数：7

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