Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T

被引：3

作者：

Wen, Qingqing ^{[1
]}

Yang, Hongyi ^{[1
,2
]}

Li, Jiali ^{[3
]}

Zhang, Jin ^{[1
]}

Tong, Haiyang ^{[1
]}

Ye, Qiong ^{[1
]}

Zhong, Kai ^{[1
,2
,4
,5
]}

机构：

[1] Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Peoples R China

[2] Univ Sci & Technol China, Hefei, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China

[4] Key Lab Anhui Prov High Field Magnet Resonance Im, Hefei, Peoples R China

[5] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2020年 / 12卷

基金：

中国国家自然科学基金;

关键词：

quantitative susceptibility mapping; iron concentration; brain aging; rhesus monkey; high resolution; 9; 4; T; ENABLED DIPOLE INVERSION; IRON CONCENTRATION; MAGNETIC-FIELD; PRIMATE MODELS; MAPPING QSM; PHASE DATA; MRI; RECONSTRUCTION; VALIDATION; COSMOS;

D O I：

10.3389/fnagi.2020.00259

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Iron concentration in the brain has been suggested as a biomarker of pathologic neurodegeneration. However, the iron concentration changes in healthy aging as well. This study aimed to quantify the age-related changes in iron concentration in the gray matter of healthy rhesus monkeys using quantitative susceptibility mapping (QSM). Three-dimensional gradient-echo images of 16 female rhesus monkey brains aged between 2 and 26 years were acquiredin vitro. The susceptibilities in the brain regions of the caudate nucleus (Cd), putamen (Pt), globus pallidus (Gp), and substantia nigra (Sn) were analyzed. The susceptibility varied across different brain regions, with higher levels in the Gp and Sn. Susceptibilities in all analyzed brain regions were linearly correlated with age, yet the plateau period as observed in human brains was absent. This is the firstin vitroreport of the age-related variability of susceptibility in the deep gray matter of rhesus monkey brains at 9.4 T, with an isotropic resolution of 150 mu m. Awareness of age-related changes in susceptibility is vital for the establishment of a baseline to facilitate the differentiation of pathologic neurodegeneration from healthy aging in non-human primate studies.

引用

页数：9