The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals

被引：12

作者：

Decloedt, E. H. ^{[1
]}

Mwansa-Kambafwile, J. ^{[2
]}

van der Walt, J-S. ^{[1
]}

McIlleron, H. ^{[1
]}

Denti, P. ^{[1
]}

Smith, P. ^{[1
]}

Wiesner, L. ^{[1
]}

Rangaka, M. ^{[2
]}

Wilkinson, R. J. ^{[2
,3
,4
]}

Maartens, G. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Med, Groote Schuur Hosp, Div Clin Pharmacol, ZA-7925 Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Infect Dis Res Initiat, ZA-7925 Cape Town, South Africa

[3] Univ London Imperial Coll Sci Technol & Med, Div Med, London, England

[4] Natl Inst Med Res, MRC, London NW7 1AA, England

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2013年 / 17卷 / 03期

基金：

美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

isoniazid; nevirapine; drug interactions; HIV; TUBERCULOSIS; ADULTS; HEPATITIS; BOTSWANA;

D O I：

10.5588/ijtld.12.0427

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Isoniazid preventive therapy (IPT) is recommended in patients on antiretroviral treatment. Isoniazid (INH) inhibits CYP3A4, which metabolises nevirapine (NVP). Administration of INH may cause higher NVP concentrations and toxicity. We studied the effect of INH on NVP concentrations in 21 patients randomised to either placebo (n = 13) or INH (n = 8) in an ongoing trial of IPT in patients on ART. INH was associated with a 24% increase in median NVP area under the plasma concentration-time curve for the 12 h dosing interval, which was not statistically significant (P = 0.66).

引用

页码：333 / 335

页数：3

共 10 条

[1] Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis [J].