Genetics of Pancreatic Neuroendocrine Tumors

被引：5

作者：

Mohindroo, Chirayu ^{[1
,2
]}

McAllister, Florencia ^{[1
,3
,4
,5
]}

De Jesus-Acosta, Ana ^{[6
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, 1515 Holcombe,Unit 1360, Houston, TX 77030 USA

[2] Sinai Hosp Baltimore, Dept Internal Med, 2435 W Belvedere Ave,Ste 56, Baltimore, MD 21215 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX USA

[5] Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, Houston, TX USA

[6] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Dept Oncol, Sch Med, CRB1,1650 Orleans St,CRB1 Rm 409, Baltimore, MD 21287 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2022年 / 36卷 / 05期

关键词：

Pancreatic neuroendocrine tumors; Germline mutations; Somatic mutations; Precision medicine; Molecular therapies; Targeted therapies; VON-HIPPEL-LINDAU; ENDOCRINE NEOPLASIA TYPE-1; OCTREOTIDE LAR; EVEROLIMUS; EFFICACY; THERAPY; MEN1; EXPRESSION; MANAGEMENT; MUTATION;

D O I：

10.1016/j.hoc.2022.07.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic testing is becoming increasingly important in the management of pNETs. Although our knowledge in the field is still evolving, advances in genetic sequencing have increased our understanding of the complex genetic mechanisms underlying pNET formation. Clinicians should consider incorporating genomic testing into treatment paradigms and involving genetic counsellors to help patients and family members with decisions regarding genetic testing, interpretation, and follow-up.

引用

页码：1033 / 1051

页数：19

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