Comparison of two-risk assessment algorithms for preeclampsia in first trimester with consecutive intake of low-dose aspirin in the high-risk group - an observational study

We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor((R))Software by PerkinElmer, PerkinElmer, Waltham, MA; PERK-group: n=214 and Viewpoint((R)) by GE Healthcare, Dornstadt, Germany; VIEW-group: n=209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic acid (LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% versus 26.3%; p=0.000). According the clinical use of screening test criteria, LDA was prescribed in 63 (29.4%) women in the PE-group and 55 (26.3%) in the VP-group (p=0.516). There were no differences in onset of preeclampsia [4 (1.9%) versus 6 (2.9%); p=0.540]. No early or severe preeclampsia occurred in the whole population.