Sesquiterpenes from the marine algicolous fungus Drechslera sp.

A marine fungal isolate, identified as Drechslera sp., was mass cultivated and found to produce a new naturally occurring seco-sativene type sesquiterpene helminthosporic acid (1) and three known sesquiterpenes, helminthosporol (2), drechslerine A (3) and (+) secolongifolene-diol (4). The structures of all compounds were determined by interpretation of their spectroscopic data 1D (H-1 and C-13), 2D (COSY, DQF, NOE, HSQC and HMBC) NMR, MS, UV and IR analyses. All compounds have been tested toward antioxidants, antimicrobial and antifouling effects. (c) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.