Protective action of intravesical oxybutynin on bladder ultrastructure in rabbits with detrusor overactivity

被引：4

作者：

Yamamoto, Hamilto ^{[2
]}

Kawano, Paulo Roberto ^{[2
]}

Balasteghin, Karina Tuma ^{[2
]}

Padovani, Carlos Roberto ^{[3
]}

Amaro, Joao Luiz ^{[1
,2
]}

机构：

[1] Fac Med Botucatu, Dept Urol, BR-18618970 Botucatu, SP, Brazil

[2] UNESP, Dept Urol, Sch Med, Botucatu, SP, Brazil

[3] UNESP, Dept Stat, Sch Med, Botucatu, SP, Brazil

来源：

INTERNATIONAL UROGYNECOLOGY JOURNAL | 2009年 / 20卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Intravesical oxybutynin; Detrusor overactivity; Rabbit; Ultrastructural; GERIATRIC VOIDING DYSFUNCTION; PARTIAL OUTLET OBSTRUCTION; CONTRACTILE DYSFUNCTION; STRUCTURAL BASIS;

D O I：

10.1007/s00192-008-0745-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To evaluate the protective effect of intravesical oxybutynin on the ultrastructure of rabbits with detrusor overactivity (DO). Seventeen North Folk male rabbits were distributed into three groups: GI (n = 5) used as control, GII (n = 5), and GIII (n = 5) with DO. One animal from GII and one from GIII were excluded because they did not develop DO. In GIII, the animals were treated with daily intravesical application of 0.5 mg/Kg of oxybutynin for 30 days. Bladder weight was significantly higher in animals from GII and GIII as compared to GI. After 30 days, cystometric study revealed that vesical capacity was significantly decreased in GII and GIII. Detrusor pressure was significantly higher in GII. Electron microscopy showed increase of intercellular space, cell junctions and caveolae areas asymmetries, mitochondria and cellular degeneration in GII, while in GIII, these alterations have improved after a 30-day treatment. Animals treated with intravesical oxybutynin presented ultrastructural aspect similar to normal.

引用

页码：229 / 234

页数：6

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