The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury

被引：39

作者：

Roberts, Veena ^{[1
]}

Lu, Bo ^{[1
]}

Rajakumar, Siddharth ^{[1
]}

Cowan, Peter J. ^{[1
]}

Dwyer, Karen M. ^{[1
]}

机构：

[1] St Vincents Hosp, Immunol Res Ctr, Melbourne, Vic 3065, Australia

来源：

PURINERGIC SIGNALLING | 2013年 / 9卷 / 02期

关键词：

Ischemia-reperfusion injury; Renal transplant; Purinergic signalling; Adenosine receptor; Ectonucleotidase; REGULATORY T-CELLS; RECEPTOR KNOCKOUT MICE; HIF-DEPENDENT INDUCTION; OF-WISCONSIN SOLUTION; ACUTE KIDNEY INJURY; ECTO-5'-NUCLEOTIDASE CD73; MYOCARDIAL PROTECTION; 5'-ADENOSINE MONOPHOSPHATE; ADENOSINE GENERATION; VASCULAR LEAKAGE;

D O I：

10.1007/s11302-012-9342-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxic injury occurs when the blood supply to an organ is interrupted; subsequent reperfusion halts ongoing ischemic damage but paradoxically leads to further inflammation. Together this is termed ischemia-reperfusion injury (IRI). IRI is inherent to organ transplantation and impacts both the short- and long-term outcomes of the transplanted organ. Activation of the purinergic signalling pathway is intrinsic to the pathogenesis of, and endogenous response to IRI. Therapies targeting the purinergic pathway in IRI are an attractive avenue for the improvement of transplant outcomes and the basis of ongoing research. This review aims to examine the role of adenosine receptor signalling and the ecto-nucleotidases, CD39 and CD73, in IRI, with a particular focus on renal IRI.

引用

页码：135 / 143

页数：9

共 102 条

[1] Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair - A randomized controlled trial [J].

Ali, Ziad A. ;

Callaghan, Chris J. ;

Lim, Eric ;

Ali, Ayyaz A. ;

Nouraei, S. A. Reza ;

Akthar, Asim M. ;

Boyle, Jonathan R. ;

Varty, Kevin ;

Kharbanda, Rajesh K. ;

Dutka, David P. ;

Gaunt, Michael E. .

CIRCULATION, 2007, 116 (11) :I98-I105

[2] CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation [J].

Banz, Yara ;

Beldi, Guido ;

Wu, Yan ;

Atkinson, Ben ;

Usheva, Anny ;

Robson, Simon C. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 142 (04) :627-637

[3] Adenosine Generation and Signaling during Acute Kidney Injury [J].

Bauerle, Jessica D. ;

Grenz, Almut ;

Kim, Jae-Hwan ;

Lee, H. Thomas ;

Eltzschig, Holger K. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (01) :14-20

[4] Resident Cardiac Immune Cells and Expression of the Ectonucleotidase Enzymes CD39 and CD73 after Ischemic Injury [J].

Boenner, Florian ;

Borg, Nadine ;

Burghoff, Sandra ;

Schrader, Juergen .

PLOS ONE, 2012, 7 (04)

[5] Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression [J].

Borsellino, Giovanna ;

Kleinewietfeld, Markus ;

Di Mitri, Diletta ;

Sternjak, Alexander ;

Diamantini, Adamo ;

Giometto, Raffaella ;

Hoepner, Sabine ;

Centonze, Diego ;

Bernardi, Giorgio ;

Dell'Acqua, Maria Luisa ;

Rossini, Paolo Maria ;

Battistini, Luca ;

Rotzschke, Olaf ;

Falk, Kirsten .

BLOOD, 2007, 110 (04) :1225-1232

[6] Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure [J].

Burne, MJ ;

Daniels, F ;

El Ghandour, A ;

Mauiyyedi, S ;

Colvin, RB ;

O'Connell, MP ;

Rabb, H .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1283-1290

[7] Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury [J].

Burne-Taney, MJ ;

Yokota-Ikeda, N ;

Rabb, H .

AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (06) :1186-1193

[8] Purine and pyrimidine receptors [J].

Burnstock, G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (12) :1471-1483

[9] Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury [J].

Cai, Ming ;

Huttinger, Zachary M. ;

He, Heng ;

Zhang, Weizhi ;

Li, Feng ;

Goodman, Lauren A. ;

Wheeler, Debra G. ;

Druhan, Lawrence J. ;

Zweier, Jay L. ;

Dwyer, Karen M. ;

He, Guanglong ;

d'Apice, Anthony J. F. ;

Robson, Simon C. ;

Cowan, Peter J. ;

Gumina, Richard J. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 51 (06) :927-935

[10] Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells [J].

Cantaluppi, Vincenzo ;

Gatti, Stefano ;

Medica, Davide ;

Figliolini, Federico ;

Bruno, Stefania ;

Deregibus, Maria C. ;

Sordi, Andrea ;

Biancone, Luigi ;

Tetta, Ciro ;

Camussi, Giovanni .

KIDNEY INTERNATIONAL, 2012, 82 (04) :412-427

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