Can Risk-Taking Be an Endophenotype for Bipolar Disorder? A Study on Patients with Bipolar Disorder Type I and Their First-Degree Relatives

被引:40
作者
Hidiroglu, Ceren [1 ]
Esen, Ozlem Demirci [1 ]
Tunca, Zeliha [2 ]
Yalcin, Sehnaz Neslihan Gurz [2 ,3 ]
Lombardo, Lauren [4 ]
Glahn, David C. [5 ,6 ]
Ozerdem, Aysegul [1 ,2 ,7 ]
机构
[1] Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkey
[2] Dokuz Eylul Univ, Fac Med, Dept Psychiat, Izmir, Turkey
[3] Etlik Zubeyde Hanim Womens Hlth Teaching & Res Ho, Ankara, Turkey
[4] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA
[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
[6] Olin Neuropsychiat Res Ctr, Inst Living Whitehall Res Bldg, Hartford, CT USA
[7] Dokuz Eylul Univ, Brain Dynam & Res Ctr, Izmir, Turkey
关键词
Bipolar disorder; Risk-taking; Impulsive behavior; Endophenotype; First-degree relative; The Balloon Analogue Risk Task; SUSTAINED ATTENTION; IMPULSIVITY; PERSONALITY; PERFORMANCE; PROPENSITY; SEVERITY; BEHAVIOR; HISTORY;
D O I
10.1017/S1355617713000015
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Risk-taking behavior and impulsivity are core features of bipolar disorder. Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for bipolar disorders, and its relationship with impulsivity and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and impulsivity respectively in 30 euthymic bipolar I patients (BD), their 25 asymptomatic first-degree relatives (BD-R), and 30 healthy controls (HC). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). BD (p < .001) and BD-R (p = .001) had similar and significantly lower adjustment scores than HC. Only BD scored significantly higher on BIS-11 total (p = .01) and motor (p = .04) subscales than HC. Neither the BART, nor impulsivity scores associated with illness features. A limitation of this study is medicated patients and a heterogeneous BD-R were included. Riskiness may be a candidate endophenotype for bipolar disorder as it appears independently from illness features, presents similarly in BD and BD-R groups and differs from impulsivity. (JINS, 2013, 19, 474-482)
引用
收藏
页码:474 / 482
页数:9
相关论文
共 45 条
[1]   Heritability of Risk-Taking in Adolescence: A Longitudinal Twin Study [J].
Anokhin, Andrey P. ;
Golosheykin, Simon ;
Grant, Julia ;
Heath, Andrew C. .
TWIN RESEARCH AND HUMAN GENETICS, 2009, 12 (04) :366-371
[2]  
[Anonymous], 2000, FORCE DSM 4 DSM 4 T, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
[3]  
Aydemir O, 2003, 7 ANN SPRING S PSYCH, P187
[4]   Sustained attention deficits in manic and euthymic patients with bipolar disorder [J].
Bora, Emre ;
Vahip, Simavi ;
Akdeniz, Fisun .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2006, 30 (06) :1097-1102
[5]   The neuropsychiatry of impulsivity [J].
Chamberlain, Samuel R. ;
Sahakian, Barbara J. .
CURRENT OPINION IN PSYCHIATRY, 2007, 20 (03) :255-261
[6]   Schizophrenia and risk-taking: Impaired reward but preserved punishment processing [J].
Cheng, Gordon L. F. ;
Tang, Joey C. Y. ;
Li, Frendi W. S. ;
Lau, Esther Y. Y. ;
Lee, Tatia M. C. .
SCHIZOPHRENIA RESEARCH, 2012, 136 (1-3) :122-127
[7]   The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder [J].
Christodouiou, T. ;
Lewis, M. ;
Ploubidis, G. B. ;
Frangou, S. .
EUROPEAN PSYCHIATRY, 2006, 21 (04) :270-273
[8]  
Cohen J., 1977, Statistical Power Analysis for the Behavioral Sciences
[9]   A Neurogenetic Approach to Impulsivity [J].
Congdon, Eliza ;
Canli, Turhan .
JOURNAL OF PERSONALITY, 2008, 76 (06) :1447-1483
[10]   Measurement of constructs using self-report and behavioral lab tasks: Is there overlap in nomothetic span and construct representation for impulsivity? [J].
Cyders, Melissa A. ;
Coskunpinar, Ayca .
CLINICAL PSYCHOLOGY REVIEW, 2011, 31 (06) :965-982